Skip Navigation



American Journal of Epidemiology Advance Access published online on April 24, 2009
American Journal of Epidemiology, doi:10.1093/aje/kwp085
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrowOA All Versions of this Article:
169/11/1281    most recent
kwp085v2
kwp085v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Disclaimer
Google Scholar
Right arrow Articles by St. Sauver, J. L.
Right arrow Articles by Jacobsen, S. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by St. Sauver, J. L.
Right arrow Articles by Jacobsen, S. J.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

American Journal of Epidemiology © 2009 The Authors
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Original Contribution

Associations Between C-Reactive Protein and Benign Prostatic Hyperplasia/Lower Urinary Tract Symptom Outcomes in a Population-based Cohort

Jennifer L. St. Sauver, Aruna V. Sarma, Debra J. Jacobson, Michaela E. McGree, Michael M. Lieber, Cynthia J. Girman, Ajay Nehra and Steven J. Jacobsen

Correspondence to Dr. Jennifer L. St. Sauver, Division of Epidemiology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905 (e-mail: stsauver.jennifer{at}mayo.edu).

Received for publication June 26, 2008. Accepted for publication November 4, 2008.

Inflammation may play a role in the development of benign prostatic hyperplasia and/or lower urinary tract symptoms (LUTS). Higher levels of C-reactive protein (CRP) may therefore be associated with the development of these outcomes. The authors examined the association of CRP levels measured in 1996 with rapid increases in prostate volume, prostate-specific antigen levels, and LUTS as well as rapid decreases in peak flow rates (through 2005) in a population-based cohort of men residing in Olmsted County, Minnesota. Men with CRP levels of ≥3.0 mg/L were more likely to have rapid increases in irritative LUTS (odds ratio (OR) = 2.14, 95% confidence interval (CI): 1.18, 3.85) and rapid decreases in peak flow rates (OR = 2.54, 95% CI: 1.09, 5.92) compared with men with CRP levels of <3.0 mg/L. CRP levels were not significantly associated with rapid increases in prostate volume, obstructive LUTS, or prostate-specific antigen levels. Associations were attenuated after adjusting for age, body mass index, hypertension, and smoking history (irritative LUTS: OR = 2.00, 95% CI: 1.04, 3.82; peak flow rate: OR = 2.45, 95% CI: 0.73, 8.25). These results suggest that rapid increases in irritative LUTS and rapid decreases in peak flow rates may be due to inflammatory processes.

C-reactive protein; inflammation; prostatic hyperplasia; signs and symptoms; urinary tract

Abbreviations: BPH, benign prostatic hyperplasia; CRP, C-reactive protein; LUTS, lower urinary tract symptoms; PSA, prostate-specific antigen

Editor's note: An invited commentary on this article appears on page 000, and the authors’ response is published on page 000.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Am J EpidemiolHome page
J. L. St. Sauver, A. V. Sarma, D. J. Jacobson, M. E. McGree, and S. J. Jacobsen
St. Sauver et al. Respond to "Lower Urinary Tract Symptoms and Inflammation"
Am. J. Epidemiol., May 8, 2009; (2009) kwp079v2.
[Full Text] [PDF]

Home page
 Am J EpidemiolHome page
S. J. Freedland and W. J. Aronson
Invited Commentary: Lower Urinary Tract Symptoms and Inflammation--Weighing the Evidence
Am. J. Epidemiol., May 8, 2009; (2009) kwp084v2.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.