American Journal of Epidemiology Advance Access published online on August 27, 2008
American Journal of Epidemiology, doi:10.1093/aje/kwn202
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Original Contribution |
Pregnancy Disorders That Lead to Delivery Before the 28th Week of Gestation: An Epidemiologic Approach to Classification
Correspondence to Dr. T. F. McElrath, Division of Maternal-Fetal Medicine, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115 (e-mail: tmcelrath{at}partners.org).
Received for publication November 2, 2007. Accepted for publication March 20, 2008.
Epidemiologists have grouped the multiple disorders that lead to preterm delivery before the 28th week of gestation in a variety of ways. The authors sought to identify characteristics that would help guide how to classify disorders that lead to such preterm delivery. They enrolled 1,006 women who delivered a liveborn singleton infant of less than 28 weeks' gestation at 14 centers in the United States between 2002 and 2004. Each delivery was classified by presentation: preterm labor (40%), prelabor premature rupture of membranes (23%), preeclampsia (18%), placental abruption (11%), cervical incompetence (5%), and fetal indication/intrauterine growth restriction (3%). Using factor analysis (eigenvalue = 1.73) to compare characteristics identified by standardized interview, chart review, placental histology, and placental microbiology among the presentation groups, the authors found 2 broad patterns. One pattern, characterized by histologic chorioamnionitis and placental microbe recovery, was associated with preterm labor, prelabor premature rupture of membranes, placental abruption, and cervical insufficiency. The other, characterized by a paucity of organisms and inflammation but the presence of histologic features of dysfunctional placentation, was associated with preeclampsia and fetal indication/intrauterine growth restriction. Disorders leading to preterm delivery may be separated into two groups: those associated with intrauterine inflammation and those associated with aberrations of placentation.
abruptio placentae; fetal growth retardation; inflammation; obstetric labor, premature; placentation; pre-eclampsia; premature birth; uterine cervical incompetence
Abbreviations: ELGAN, Extremely Low Gestational Age Newborns; IUGR, intrauterine growth restriction; pPROM, prelabor premature rupture of membranes
Editor's note: An invited commentary on this article appears on page 000, and the authors' response is on page 000.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  H. A. Boyd, G. Poulsen, J. Wohlfahrt, J. C. Murray, B. Feenstra, and M. Melbye Maternal Contributions to Preterm Delivery Am. J. Epidemiol., December 1, 2009; 170(11): 1358 - 1364. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. R. Kramer and C. R. Hogue What Causes Racial Disparities in Very Preterm Birth? A Biosocial Perspective Epidemiol. Rev., November 1, 2009; 31(1): 84 - 98. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. F. McElrath, E. N. Allred, K. A. Boggess, K. Kuban, T. M. O'Shea, N. Paneth, and Alan Leviton for the ELGAN Study Investigators Maternal Antenatal Complications and the Risk of Neonatal Cerebral White Matter Damage and Later Cerebral Palsy in Children Born at an Extremely Low Gestational Age Am. J. Epidemiol., October 1, 2009; 170(7): 819 - 828. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Malaeb and O. Dammann Fetal Inflammatory Response and Brain Injury in the Preterm Newborn J Child Neurol, September 1, 2009; 24(9): 1119 - 1126. [Abstract] [PDF]
|
|
|
|
 |
|
 C. Bose, L. J. Van Marter, M. Laughon, T. M. O'Shea, E. N. Allred, P. Karna, R. A. Ehrenkranz, K. Boggess, A. Leviton, and for the Extremely Low Gestational Age Newborn Stud Fetal Growth Restriction and Chronic Lung Disease Among Infants Born Before the 28th Week of Gestation Pediatrics, September 1, 2009; 124(3): e450 - e458. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Laughon, M. T. O'Shea, E. N. Allred, C. Bose, K. Kuban, L. J. Van Marter, R. A. Ehrenkranz, A. Leviton, and for the ELGAN Study Investigators Chronic Lung Disease and Developmental Delay at 2 Years of Age in Children Born Before 28 Weeks' Gestation Pediatrics, August 1, 2009; 124(2): 637 - 648. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. F. McElrath and J. L. Hecht Invited Commentary: Intrauterine Epidemiology Am. J. Epidemiol., July 15, 2009; 170(2): 159 - 161. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. A. Savitz Invited Commentary: Disaggregating Preterm Birth to Determine Etiology Am. J. Epidemiol., November 1, 2008; 168(9): 990 - 992. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. F. McElrath, J. L. Hecht, O. Dammann, K. Boggess, A. Onderdonk, G. Markenson, M. Harper, E. Delpapa, E. N. Allred, and A. Leviton McElrath et al. Respond to "Disaggregating Preterm Birth" Am. J. Epidemiol., November 1, 2008; 168(9): 993 - 994. [Full Text] [PDF]
|
|