Skip Navigation



American Journal of Epidemiology Advance Access published online on November 6, 2007
American Journal of Epidemiology, doi:10.1093/aje/kwm301
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
167/3/305    most recent
kwm301v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Zablotska, L. B.
Right arrow Articles by Tronko, M. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Zablotska, L. B.
Right arrow Articles by Tronko, M. D.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

American Journal of Epidemiology © The Author 2007. Published by the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org.

Original Contribution

A Cohort Study of Thyroid Cancer and Other Thyroid Diseases after the Chornobyl Accident: Dose-Response Analysis of Thyroid Follicular Adenomas Detected during First Screening in Ukraine (1998–2000)

Lydia B. Zablotska1,*, Tetyana I. Bogdanova2, Elaine Ron3, Ovsiy V. Epstein {dagger}, Jacob Robbins4, Illya A. Likhtarev5, Maureen Hatch3, Valentyn V. Markov2, Andre C. Bouville3, Valery A. Olijnyk2, Robert J. McConnell6, Victor M. Shpak2, Alina Brenner3, Galina N. Terekhova2, Ellen Greenebaum7, Valery P. Tereshchenko2, Daniel J. Fink7, Aaron B. Brill8, Galina A. Zamotayeva2, Ihor J. Masnyk3, Geoffrey R. Howe {dagger} and Mykola D. Tronko2

1 Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY
2 Institute of Endocrinology and Metabolism, Kyiv, Ukraine
3 Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD
4 Genetics and Biochemistry Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD
5 Scientific Center for Radiation Medicine, Academy of Medical Sciences, Kyiv, Ukraine
6 Department of Medicine, The Thyroid Clinic, College of Physicians and Surgeons, Columbia University, New York, NY
7 Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, NY
8 Department of Radiation and Radiological Sciences, School of Medicine, Vanderbilt University, Nashville, TN

* Correspondence to Dr. Lydia B. Zablotska, Mailman School of Public Health, Columbia University, 722 West 168th Street, Suite 1103, New York, NY 10032 (e-mail: lbz7{at}columbia.edu).

Received for publication May 17, 2007. Accepted for publication September 19, 2007.

The Chornobyl (Chernobyl) accident in 1986 exposed many individuals to radioactive iodines, chiefly 131I, the effects of which on benign thyroid diseases are largely unknown. To investigate the risk of follicular adenoma in relation to radiation dose after Chornobyl, the authors analyzed the baseline data from a prospective screening cohort study of those exposed as children or adolescents. A stratified random sample was selected from all individuals who were younger than 18 years, had thyroid radioactivity measurements taken within 2 months after the accident, and resided in the three heavily contaminated areas in Ukraine. This analysis is based on the 23 cases diagnosed in 12,504 subjects for whom personal history of thyroid diseases was known. The dose-response relation was linear with an excess relative risk of 2.07 per gray (95% confidence interval: 0.28, 10.31). The risk was significantly higher in women compared with men, with no clear modifying effects of age at exposure. In conclusion, persons exposed to radioactive iodines as children and adolescents have an increased risk of follicular adenoma, though it is smaller than the risk of thyroid cancer in the same cohort. Compared with results from other studies, this estimate is somewhat smaller, but confidence intervals overlap, suggesting compatibility.

adenoma; Chernobyl nuclear accident; dose-response relationship, radiation; iodine; thyroid neoplasms

Abbreviations: CI, confidence interval

{dagger} Deceased.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.