American Journal of Epidemiology Advance Access published online on September 5, 2007
American Journal of Epidemiology, doi:10.1093/aje/kwm217
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Original Contribution |
Occupational Noise Exposure and Risk of Acoustic Neuroma
1 Division of Epidemiology, College of Public Health, The Ohio State University, Columbus, OH
2 Division of Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
3 Division of Occupational Medicine, Department of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden
4 Department of Epidemiology, University of North Carolina School of Public Health, Chapel Hill, NC
Correspondence to Dr. Colin Edwards, Division of Epidemiology, College of Public Health, The Ohio State University, Starling-Loving Hall, Room A446, 320 West Tenth Avenue, Columbus, OH 43210 (e-mail: colin.edwards{at}osumc.edu).
Received for publication May 22, 2007. Accepted for publication June 28, 2007.
A small number of prior epidemiologic studies of occupational noise exposure based on self-report have suggested an association with acoustic neuroma. The goal of the present study was to further examine the association between noise exposure and acoustic neuroma by using an objective measure of exposure in the form of a job exposure matrix. A total of 793 acoustic neuroma cases aged 21–84 years were identified between 1987 and 1999 from the Swedish Cancer Registry. The 101,756 controls randomly selected from the study base were frequency matched to cases on age, sex, and calendar year of diagnosis. Occupational information, available for 599 of the cases and 73,432 of the controls, was obtained from censuses and was linked to a job exposure matrix based on actual noise measurements. All risk estimates were close to unity, regardless of noise exposure level or parameter. The overall odds ratio for exposure to 
85 dB of noise was 0.89 (95% confidence interval: 0.64, 1.23). Contrary to previous study results, the present findings did not demonstrate an increased acoustic neuroma risk related to occupational noise exposure even after allowing for a long latency period. The effect of nondifferential misclassification of exposure must be considered a potential cause of the negative findings.
case-control studies; neuroma, acoustic; noise; risk factors
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  M Hours, M Bernard, M Arslan, L Montestrucq, L Richardson, I Deltour, and E Cardis Can loud noise cause acoustic neuroma? Analysis of the INTERPHONE study in France Occup. Environ. Med., July 1, 2009; 66(7): 480 - 486. [Abstract] [Full Text] [PDF]
|
|