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American Journal of Epidemiology Advance Access published online on June 18, 2007
American Journal of Epidemiology, doi:10.1093/aje/kwm158
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American Journal of Epidemiology Copyright © 2007 by the Johns Hopkins Bloomberg School of Public Health All rights reserved; printed in U.S.A.

Letter to the Editor

RE: "CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA AND INFECTIONS IN THE FIRST YEAR OF LIFE: A REPORT FROM THE UNITED KINGDOM CHILDHOOD CANCER STUDY"

M. Tevfik Dorak1,2, Richard J. Q. McNally1 and Louise Parker3

1 Sir James Spence Institute of Child Health, School of Clinical Medical Sciences, Faculty of Medical Sciences, Newcastle University, Newcastle NE1 4LP, United Kingdom
2 Current affiliation: Genomic Immunoepidemiology Division, HUMIGEN, Institute for Genetic Immunology, Hamilton, NJ 08690
3 Community Health and Epidemiology, Department of Paediatrics, Dalhousie University IWK Health Centre, Halifax, Nova Scotia B3K 6R8, Canada

(e-mail: dorakmt@dorak.info)

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In the latest report from the United Kingdom Childhood Cancer Study (UKCCS), Roman et al. (1) describe an association between early-onset childhood acute lymphoblastic leukemia (ALL) and increased early infections. This study is a welcome development, following the studies that used proxy measures for infectious exposure (2). Roman et al. concede that the results do not support Greaves' delayed infection hypothesis (3) but conclude . . . [Full Text of this Article]


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Am. J. Epidemiol., August 1, 2007; 166(3): 365 - 365.
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