American Journal of Epidemiology Advance Access published online on May 10, 2007
American Journal of Epidemiology, doi:10.1093/aje/kwm130
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Invited Commentary: Physical Activity, Mortality, and Genetics
From the Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA
Correspondence to Dr. Tuomo Rankinen, Human Genomics Laboratory, Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808 (e-mail: rankint{at}pbrc.edu).
Received for publication February 5, 2007. Accepted for publication March 2, 2007.
The importance of regular physical activity to human health has been recognized for a long time, and a physically active lifestyle is now defined as a major component of public health policies. The independent contribution of regular physical activity to lower morbidity and mortality rates is generally accepted, and the biologic mechanisms mediating these health effects are actively investigated. A few years ago, data from the Finnish Twin Registry suggested that genetic selection may account for some of the physical-activity-related benefits on mortality rates. However, results from the Swedish Twin Registry study reported by Carlsson et al. in the current issue of the Journal (Am J Epidemiol 2007;166:000–00) do not support the genetic selection hypothesis. In this commentary, the authors review the nature of the associations among physical activity level, fitness, and longevity, with special reference to the role of human genetic variation, and discuss potential reasons for different outcomes of these large twin studies.
mortality; motor activity; questionnaires; selection (genetics); Sweden; twins
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