American Journal of Epidemiology Advance Access published online on April 21, 2007
American Journal of Epidemiology, doi:10.1093/aje/kwm049
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Original Contribution |
Body Mass and Colorectal Cancer Risk in the NIH–AARP Cohort
1 Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD
2 Biometry Research Group, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD
3 AARP, Washington, DC
Correspondence to Dr. Kenneth F. Adams, 6120 Executive Boulevard, Rockville, MD 20852 (e-mail: adamske{at}mail.nih.gov).
Received for publication September 9, 2006. Accepted for publication January 5, 2007.
In most studies, body mass index (BMI) has been associated with increased risk of colorectal or colon cancer in men, but the relation is weaker and less consistent for women, possibly because of interactions with age or hormone replacement therapy. The authors examined the relation between BMI and colorectal cancer incidence in a large, prospective US cohort of 307,708 men and 209,436 women from the NIH–AARP Diet and Health Study. During follow-up of the cohort from 1995 to 2000, 2,314 cases of colorectal cancer were observed in men and 1,029 in women. BMI was related to increased risk of incident colon cancer, but not rectal cancer, for both men and women. For men, relative risks of colon cancer for a BMI of 18.5–<23, 23–<25, 25–<27.5, 27.5–<30, 30–<32.5, 32.5–<35, 35–<40, and 
40 kg/m2 were 1.0 (referent), 1.11, 1.22, 1.44, 1.53, 1.57, 1.71, and 2.39, respectively (95% confidence interval: 1.59, 3.58; p-trend < 0.0005). Corresponding relative risks for women were 1.0, 1.20, 1.29, 1.31, 1.28, 1.13, 1.46, and 1.49 (95% confidence interval: 0.98, 2.25; p-trend = 0.02). BMI was related to colon cancer risk for younger (aged 50–66 years) but not older (aged 67–71 years) women. The association was not modified by hormone replacement therapy in women or physical activity in men or women.
body mass index; colonic neoplasms; colorectal neoplasms; humans; obesity; overweight; rectal neoplasms
Abbreviations: BMI, body mass index; HRT, hormone replacement therapy; NIH, National Institutes of Health
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