American Journal of Epidemiology Advance Access published online on April 9, 2007
American Journal of Epidemiology, doi:10.1093/aje/kwm045
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Original Contribution |
Smoking Cigarettes before First Childbirth and Risk of Breast Cancer
1 Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD
2 Department of Preventive Medicine, Dankook University College of Medicine, Cheonan, Korea
3 Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD
4 Bioinformatics and Statistics, Netherlands Cancer Institute, Amsterdam, The Netherlands
Correspondence to Dr. Mina Ha, Department of Preventive Medicine, Dankook University College of Medicine, San 29 Anseo-Dong, Cheonan, Chungnam 330-714, Korea (e-mail: minaha{at}dankook.ac.kr).
Received for publication July 31, 2006. Accepted for publication January 5, 2007.
Inconsistent epidemiologic findings on cigarette smoking and female breast cancer risk may reflect insufficient assessment of smoking onset and amount relative to reproductive events. To determine the risk of breast cancer associated with smoking during different periods of reproductive life, the authors evaluated 906 incident breast cancer cases in a nationwide cohort of 56,042 female US radiologic technologists (1983–1998) who responded to two questionnaire surveys. After they accounted for age, birth cohort, and established breast cancer risk factors, smoking-related breast cancer risks differed by smoking during three reproductive time periods (p = 0.003), with a statistically significant 3% increase per pack-year of smoking between menarche and first childbirth (relative risk = 1.03, 95% confidence interval: 1.02, 1.05) and no significant association for smoking after first childbirth. Risk also increased with younger age at smoking initiation (p-trend = 0.06), after adjustment for pack-years of smoking before and after first childbirth, indicating an independent effect of age at smoking initiation. The findings from this study suggest that sensitivity of the female breast to tobacco carcinogens is increased during adolescence and early adulthood but decreases after first childbirth, when most breast tissue has terminally differentiated.
breast neoplasms; reproduction; smoking
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