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American Journal of Epidemiology Advance Access published online on March 10, 2007
American Journal of Epidemiology, doi:10.1093/aje/kwk115
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American Journal of Epidemiology Copyright © 2007 by the Johns Hopkins Bloomberg School of Public Health All rights reserved; printed in U.S.A.

PRACTICE OF EPIDEMIOLOGY

Age, Gene/Environment Susceptibility–Reykjavik Study: Multidisciplinary Applied Phenomics

Tamara B. Harris1, Lenore J. Launer1, Gudny Eiriksdottir2, Olafur Kjartansson3, Palmi V. Jonsson4,5, Gunnar Sigurdsson5,6, Gudmundur Thorgeirsson5,7, Thor Aspelund2, Melissa E. Garcia1, Mary Frances Cotch8, Howard J. Hoffman9, Vilmundur Gudnason2,5 for the Age, Gene/Environment Susceptibility–Reykjavik Study Investigators

1 Laboratory of Epidemiology, Demography, and Biometry, Intramural Research Program, National Institute on Aging, Bethesda, MD
2 Icelandic Heart Association, Kopavogur, Iceland
3 Department of Radiology, Landspitali University Hospital, Reykjavik, Iceland
4 Department of Geriatrics, Landspitali University Hospital, Reykjavik, Iceland
5 Faculty of Medicine, University of Iceland, Reykjavik, Iceland
6 Department of Endocrinology and Metabolism, Landspitali University Hospital, Reykjavik, Iceland
7 Department of Medicine, Landspitali University Hospital, Reykjavik, Iceland
8 Division of Epidemiology and Clinical Research, National Eye Institute, Bethesda, MD
9 Epidemiology and Biostatistics Program, National Institute of Deafness and Communication Disorders, Bethesda, MD

Correspondence to Dr. Tamara B. Harris or Dr. Lenore J. Launer, Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, 7201 Wisconsin Avenue, Suite 3C309, Bethesda, MD 20892-9205 (e-mail: Harris99{at}mail.nih.gov or LaunerL{at}mail.nih.gov) or Dr. Vilmundur Gudnason, Icelandic Heart Association, Holtasmara 1, 201 Kopavogur, Iceland (e-mail: v.gudnason{at}hjarta.is).

Received for publication April 14, 2006. Accepted for publication October 24, 2006.

In anticipation of the sequencing of the human genome and description of the human proteome, the Age, Gene/Environment Susceptibility–Reykjavik Study (AGES–Reykjavik) was initiated in 2002. AGES–Reykjavik was designed to examine risk factors, including genetic susceptibility and gene/environment interaction, in relation to disease and disability in old age. The study is multidisciplinary, providing detailed phenotypes related to the cardiovascular, neurocognitive (including sensory), and musculoskeletal systems, and to body composition and metabolic regulation. Relevant quantitative traits, subclinical indicators of disease, and medical diagnoses are identified by using biomarkers, imaging, and other physiologic indicators. The AGES–Reykjavik sample is drawn from an established population-based cohort, the Reykjavik Study. This cohort of men and women born between 1907 and 1935 has been followed in Iceland since 1967 by the Icelandic Heart Association. The AGES–Reykjavik cohort, with cardiovascular risk factor assessments earlier in life and detailed late-life phenotypes of quantitative traits, will create a comprehensive study of aging nested in a relatively genetically homogeneous older population. This approach should facilitate identification of genetic factors that contribute to healthy aging as well as the chronic conditions common in old age.

aging; body composition; cardiovascular diseases; cognition; genetics, population; osteoporosis; phenotype

Abbreviations: AGES–Reykjavik, Age, Gene/Environment Susceptibility–Reykjavik Study


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