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American Journal of Epidemiology Advance Access published online on January 27, 2007
American Journal of Epidemiology, doi:10.1093/aje/kwk072
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American Journal of Epidemiology Copyright © 2007 by the Johns Hopkins Bloomberg School of Public Health All rights reserved; printed in U.S.A.

ORIGINAL CONTRIBUTION

Nine-Year Changes in Cardiovascular Disease Risk Factors with Weight Maintenance in the Atherosclerosis Risk in Communities Cohort

Kimberly P. Truesdale1, June Stevens1,2 and Jianwen Cai3

1 Department of Nutrition, School of Public Health, University of North Carolina, Chapel Hill, NC
2 Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC
3 Department of Biostatistics, School of Public Health, University of North Carolina, Chapel Hill, NC

Correspondence to Dr. Kimberly Truesdale, Department of Nutrition, CB 7456, University of North Carolina, Chapel Hill, NC 27599 (e-mail: Kim_Truesdale{at}unc.edu).

Few studies have focused on the impact of weight maintenance on cardiovascular disease risk factors or addressed whether changes differ by baseline weight status and medication usage. The authors examined these issues using 9 years of follow-up data on 3,235 men and women from the Atherosclerosis Risk in Communities (ARIC) Study who were aged 45–64 years at baseline (1987–1989). In participants not using medications, glucose (3.0 mg/dl, 95% confidence interval (CI): 2.4, 3.5) and triglycerides (10.1 mg/dl, 95% CI: 8.3, 11.9) increased, while total cholesterol (–9.6 mg/dl, 95% CI: –10.6, –8.6), low density lipoprotein cholesterol (–9.9 mg/dl, 95% CI: –10.9, –9.0), and high density lipoprotein cholesterol (–1.7 mg/dl, 95% CI: –2.1, –1.3) decreased. Systolic blood pressure (7.9 mmHg, 95% CI: 7.3, 8.4) increased, but diastolic blood pressure (–1.1 mmHg, 95% CI: –1.4, –0.7) declined. Normal weight (body mass index: 18.5–<25.0 kg/m2) participants had smaller increases in glucose compared with obese (body mass index: ≥30.0 kg/m2) participants. In contrast, the authors found less favorable changes in total, low density lipoprotein, and high density lipoprotein cholesterol, triglycerides, and diastolic blood pressure among normal weight compared with obese participants who maintained their weight. These patterns were similar across weight status groups regardless of medication usage.

blood pressure; cholesterol, HDL; cholesterol, LDL; glucose; obesity; triglycerides; weight gain; weight loss

Abbreviations: ARIC, Atherosclerosis Risk in Communities; CARDIA, Coronary Artery Risk Development in Young Adults; HDL, high density lipoprotein; LDL, low density lipoprotein


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