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American Journal of Epidemiology Advance Access published online on November 20, 2006
American Journal of Epidemiology, doi:10.1093/aje/kwk021
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American Journal of Epidemiology Copyright © 2006 by the Johns Hopkins Bloomberg School of Public Health All rights reserved; printed in U.S.A.
Received July 12, 2005
Accepted July 11, 2006

ORIGINAL CONTRIBUTIONS

Effects of Past and Recent Blood Pressure and Cholesterol Level on Coronary Heart Disease and Stroke Mortality, Accounting for Measurement Error

Hendriek C. Boshuizen 1 *, Mariapaola Lanti 2, Alessandro Menotti 2, Joanna Moschandreas 3, Hanna Tolonen 4, Aulikki Nissinen 4, Srecko Nedeljkovic 5, Anthony Kafatos 3, and Daan Kromhout 6

1 National Institute for Public Health and the Environment, Bilthoven, the Netherlands
2 Association for Cardiac Research, Rome, Italy
3 Department of Preventive Medicine and Nutrition Clinic, Medical School, University of Crete, Heraklion, Crete, Greece
4 Department of Health Promotion and Chronic Disease Prevention, National Public Health Institute, Helsinki, Finland
5 Institute for Cardiovascular Diseases, Clinical Center of Serbia, Beograd, Serbia-Montenegro
6 National Institute for Public Health and the Environment, Bilthoven, the Netherlands; Division of Human Nutrition, Wageningen University, Wageningen, the Netherlands

* To whom correspondence should be addressed.
Hendriek C. Boshuizen, E-mail: hendriek.boshuizen{at}rivm.nl


  Abstract

The authors aimed to quantify the effects of current systolic blood pressure (SBP) and serum total cholesterol on the risk of mortality in comparison with SBP or serum cholesterol 25 years previously, taking measurement error into account. The authors reanalyzed 35-year follow-up data on mortality due to coronary heart disease and stroke among subjects aged 65 years or more from nine cohorts of the Seven Countries Study. The two-step method of Tsiatis et al. (J Am Stat Assoc 1995;90:27-37) was used to adjust for regression dilution bias, and results were compared with those obtained using more commonly applied methods of adjustment for regression dilution bias. It was found that the commonly used univariate adjustment for regression dilution bias overestimates the effects of both SBP and cholesterol compared with multivariate methods. Also, the two-step method makes better use of the information available, resulting in smaller confidence intervals. Results comparing recent and past exposure indicated that past SBP is more important than recent SBP in terms of its effect on coronary heart disease mortality, while both recent and past values seem to be important for effects of cholesterol on coronary heart disease mortality and effects of SBP on stroke mortality. Associations between serum cholesterol concentration and risk of stroke mortality are weak.

Keywords: blood pressure; cerebrovascular accident; cholesterol; coronary disease; epidemiologic methods.
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RE: "EFFECTS OF PAST AND RECENT BLOOD PRESSURE AND CHOLESTEROL LEVEL ON CORONARY HEART DISEASE AND STROKE MORTALITY, ACCOUNTING FOR MEASUREMENT ERROR"
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Home page
 Am J EpidemiolHome page
H. C. Boshuizen, M. Lanti, A. Menotti, J. Moschandreas, H. Tolonen, A. Nissinen, S. Nedeljkovic, A. Kafatos, and D. Kromhout
THE AUTHORS REPLY
Am. J. Epidemiol., February 15, 2008; 167(4): 503 - 504.
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