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American Journal of Epidemiology Advance Access published online on November 16, 2006
American Journal of Epidemiology, doi:10.1093/aje/kwk013
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American Journal of Epidemiology Copyright © 2006 by the Johns Hopkins Bloomberg School of Public Health All rights reserved; printed in U.S.A.
Received May 12, 2006
Accepted June 28, 2006

ORIGINAL CONTRIBUTIONS

Coffee Consumption and Risk of Myocardial Infarction among Older Swedish Women

Sarah A. Rosner 1 *, Agneta Åkesson 2, Meir J. Stampfer 3, and Alicja Wolk 2

1 Department of Epidemiology, Harvard School of Public Health, Boston, MA
2 Division of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
3 Department of Epidemiology, Harvard School of Public Health, Boston, MA; Division of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden

* To whom correspondence should be addressed.
Sarah A. Rosner, E-mail: srosner{at}hsph.harvard.edu


  Abstract

Numerous studies have examined the association between coffee consumption and risk of myocardial infarction (MI), but results have been inconsistent. Case-control studies generally suggest a harmful effect of coffee drinking, whereas cohort studies have mostly shown no association. Recent studies found that coffee may lower the risk of diabetes, a major coronary risk factor. The authors prospectively examined the effect of coffee consumption on MI risk in 32,650 older Swedish women, aged 40-74 years, participating in the Swedish Mammography Cohort; 459 cases of MI developed during 165,896 person-years of follow-up from 1997 to 2002. After adjustment for age, coronary heart disease risk factors, and dietary variables, the relative risk of MI associated with drinking ≥5 cups/week versus 0-4 cups/week was 0.68 (95% confidence interval (CI): 0.43, 1.07). The authors observed a nonsignificant trend toward lower risk with higher consumption levels. Compared with that for 0-4 cups/week, the relative risks of MI were 0.84 (95% CI: 0.51, 1.38) for 5-7 cups/week, 0.65 (95% CI: 0.41, 1.03) for 2-3 cups/day, 0.64 (95% CI: 0.39, 1.04) for 4-5 cups/day, and 0.65 (95% CI: 0.37, 1.12) for ≥6 cups/day (p-trend = 0.07). Contrary to previous case-control studies, the authors concluded that coffee consumption does not increase MI risk. Coffee consumption of ≥5 cups/week was nonsignificantly inversely associated with MI risk among older Swedish women.

Keywords: coffee; myocardial infarction; Sweden; women.
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