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American Journal of Epidemiology Advance Access published online on November 7, 2006
American Journal of Epidemiology, doi:10.1093/aje/kwk008
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American Journal of Epidemiology Copyright © 2006 by the Johns Hopkins Bloomberg School of Public Health All rights reserved; printed in U.S.A.
Received February 23, 2006
Accepted June 15, 2006

ORIGINAL CONTRIBUTIONS

Survival Differences by Race in Nasopharyngeal Carcinoma

Li-Min Sun 1 *, Christopher I. Li 2, Eng-Yen Huang 3, and Thomas L. Vaughan 2

1 Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA; Department of Epidemiology, University of Washington, Seattle, WA; Department of Radiation Oncology, Chang Gung Memorial Hospital, Kaohsiung Hsien, Taiwan, Republic of China
2 Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA; Department of Epidemiology, University of Washington, Seattle, WA
3 Department of Radiation Oncology, Chang Gung Memorial Hospital, Kaohsiung Hsien, Taiwan, Republic of China; School of Traditional Chinese Medicine, Chang Gung University, Taipei, Taiwan, Republic of China

* To whom correspondence should be addressed.
Li-Min Sun, E-mail: sunlm1010{at}yahoo.com.tw


  Abstract

Incidence rates of nasopharyngeal carcinoma (NPC) are much higher among Chinese than they are among most other racial/ethnic groups around the world. With respect to NPC, results from survival studies are mixed, as some studies have and others have not found differences by race/ethnicity. Using Surveillance, Epidemiology, and End Results (SEER) Program data, the authors used a multivariate Cox proportional hazards regression model to evaluate differences in risk of mortality among NPC patients across Chinese, non-Hispanic White, Black, and Filipino populations in the United States. From 1973 to 2002, 3,952 patients with microscopically confirmed NPC were identified across SEER 9 registries. After controlling for SEER registry, age at diagnosis, year of diagnosis, gender, World Health Organization type of grade histology, stage, and use of radiotherapy, the authors found that Chinese NPC patients had lower risks of overall mortality compared with non-Hispanic White patients (hazard ratio = 0.73, 95 percent confidence interval: 0.64, 0.84). However, no differences in risk of NPC cause-specific mortality were observed by race/ethnicity. Despite having higher incidence rates of NPC compared with other groups, Chinese NPC patients in the United States have better overall survival and the same risks of NPC-related mortality compared with other racial/ethnic groups.

Keywords: continental population groups; nasopharyngeal neoplasms; survival.
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