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American Journal of Epidemiology Advance Access published online on October 27, 2006
American Journal of Epidemiology, doi:10.1093/aje/kwj367
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American Journal of Epidemiology Copyright © 2006 by the Johns Hopkins Bloomberg School of Public Health All rights reserved; printed in U.S.A.
Received December 24, 2005
Accepted May 26, 2006

ORIGINAL CONTRIBUTIONS

Chromosomal Aberrations and Cancer Risk: Results of a Cohort Study from Central Europe

Paolo Boffetta 1 *, Olga van der Hel 1, Hannu Norppa 2, Eleonora Fabianova 3, Aleksandra Fucic 4, Sarolta Gundy 5, Juozas Lazutka 6, Antonina Cebulska-Wasilewska 7, Daniela Puskailerova 3, Ariana Znaor 8, Zsolt Kelecsenyi 5, Juozas Kurtinaitis 9, Jadwiga Rachtan 10, Alessandra Forni 11, Roel Vermeulen 12, and Stefano Bonassi 13

1 International Agency for Research on Cancer, Lyon, France
2 Finnish Institute of Occupational Health, Helsinki, Finland
3 Regional Public Health Authority, Banska Bystrica, Slovakia
4 Institute for Medical Research and Occupational Health, Zagreb, Croatia
5 National Institute of Oncology, Budapest, Hungary
6 Vilnius University, Vilnius, Lithuania
7 Epidemiology Department, Jagellonian University Medical College, Kraków, Poland; Institute of Nuclear Physics, Polish Academy of Sciences, Kraków, Poland
8 Croatian National Cancer Registry, Zagreb, Croatia
9 Lithuanian Cancer Register, Vilnius University Institute of Oncology, Vilnius, Lithuania
10 Cancer Epidemiology Department, Institute of Oncology, Kraków Branch, Kraków, Poland
11 Department of Occupational and Environmental Health, University of Milan, Milan, Italy
12 National Cancer Institute, Bethesda, MD
13 Unit of Molecular Epidemiology, National Cancer Research Institute, Genoa, Italy

* To whom correspondence should be addressed.
Paolo Boffetta, E-mail: boffetta{at}iarc.fr


  Abstract

A high level of chromosomal aberrations in peripheral blood lymphocytes may be an early marker of cancer risk, but data on risk of specific cancers and types of chromosomal aberrations (chromosome type and chromatid type) are limited. A total of 6,430 healthy individuals from nine laboratories in Croatia, Hungary, Lithuania, Poland, and Slovakia, included in chromosomal aberration surveys performed during 1978-2002, were followed up for cancer incidence or mortality for an average of 8.5 years; 200 cancer cases were observed. Compared with that for the low-tertile level of chromosomal aberrations, the relative risks of cancer for the medium and high tertiles were 1.78 (95% confidence interval: 1.19, 2.67) and 1.81 (95% confidence interval: 1.20, 2.73), respectively. The relative risk for chromosome-type aberrations above versus below the median was 1.50 (95% confidence interval: 1.12, 2.01), while that for chromatid-type aberrations was 0.97 (95% confidence interval: 0.72, 1.31). The analyses of risk of specific cancers were limited by small numbers, but the association was stronger for stomach cancer. This study confirms the previously reported association between level of chromosomal aberrations and cancer risk and provides novel information on the type of aberrations more strongly predictive of cancer risk and on the types of cancer more strongly predicted by chromosomal aberrations.

Keywords: chromosome aberrations; cohort studies; cytogenetics; Europe; neoplasms; risk.
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