American Journal of Epidemiology Advance Access published online on October 26, 2006
American Journal of Epidemiology, doi:10.1093/aje/kwj366
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI
* To whom correspondence should be addressed. Investigators studying associations between vegetable intake and pancreatic cancer risk have reported inconsistent findings to date. To further explore these associations, the authors analyzed data on 183,522 participants enrolled in the Hawaii-Los Angeles Multiethnic Cohort Study in 1993-1996. Intakes of total vegetables, light green, dark green, yellow-orange, and cruciferous vegetables, tomato products, and legumes were estimated from a quantitative food frequency questionnaire. After an average of 8.3 years of follow-up, 529 pancreatic cancer cases were identified. Multivariate-adjusted Cox proportional hazards models were created. All statistical tests were two-sided. Overall, total vegetable intake was not associated with pancreatic cancer risk, nor was intake of vegetable subgroups. Current smokers, who were at increased risk of pancreatic cancer (relative risk = 1.78, 95% confidence interval: 1.40, 2.27), had a decreased risk with higher intake of dark green vegetables (for comparison of extreme quartiles, relative risk = 0.50, 95% confidence interval: 0.27, 0.92; p-trend = 0.029). The inverse association for dark green vegetables was also seen in African Americans (p-trend = 0.043). In stratified analyses, inverse associations with total vegetables, light green vegetables, and legumes were significant in overweight/obese subjects. In conclusion, the authors found no evidence for an inverse association between vegetable intake and pancreatic cancer overall, but inverse associations in high-risk persons suggest the need for further investigation.
Received November 30, 2005
Accepted June 8, 2006
ORIGINAL CONTRIBUTIONS
Vegetable Intake and Pancreatic Cancer Risk: The Multiethnic Cohort Study
Ute Nöthlings 1 *, Lynne R. Wilkens 1, Suzanne P. Murphy 1, Jean H. Hankin 1, Brian E. Henderson 2, and Laurence N. Kolonel 1
2 Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA
Ute Nöthlings, E-mail: ute.noethlings{at}dife.de
Abstract 
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  U. Nothlings, S. P Murphy, L. R Wilkens, H. Boeing, M. B Schulze, H B. Bueno-de-Mesquita, D. S Michaud, A. Roddam, S. Rohrmann, A. Tjonneland, et al. A food pattern that is predictive of flavonol intake and risk of pancreatic cancer Am. J. Clinical Nutrition, December 1, 2008; 88(6): 1653 - 1662. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Bobe, S. J. Weinstein, D. Albanes, T. Hirvonen, J. Ashby, P. R. Taylor, J. Virtamo, and R. Z. Stolzenberg-Solomon Flavonoid Intake and Risk of Pancreatic Cancer in Male Smokers (Finland) Cancer Epidemiol. Biomarkers Prev., March 1, 2008; 17(3): 553 - 562. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 U. Nothlings, S. P. Murphy, L. R. Wilkens, B. E. Henderson, and L. N. Kolonel Flavonols and Pancreatic Cancer Risk: The Multiethnic Cohort Study Am. J. Epidemiol., October 15, 2007; 166(8): 924 - 931. [Abstract] [Full Text] [PDF]
|
|