Skip Navigation



American Journal of Epidemiology Advance Access published online on October 3, 2006
American Journal of Epidemiology, doi:10.1093/aje/kwj328
This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
164/12/1160    most recent
kwj328v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Stein, A. D.
Right arrow Articles by Martorell, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Stein, A. D.
Right arrow Articles by Martorell, R.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

American Journal of Epidemiology Copyright © 2006 by the Johns Hopkins Bloomberg School of Public Health All rights reserved; printed in U.S.A.
Received November 14, 2005
Accepted May 1, 2006

ORIGINAL CONTRIBUTIONS

Exposure to a Nutrition Supplementation Intervention in Early Childhood and Risk Factors for Cardiovascular Disease in Adulthood: Evidence from Guatemala

Aryeh D. Stein 1 *, Meng Wang 1, Manuel Ramirez-Zea 2, Rafael Flores 1, Ruben Grajeda 2, Paul Melgar 2, Usha Ramakrishnan 1, and Reynaldo Martorell 1

1 Rollins School of Public Health, Emory University, Atlanta, GA
2 Institute of Nutrition of Central America and Panama (INCAP), Guatemala City, Guatemala

* To whom correspondence should be addressed.
Aryeh D. Stein, E-mail: Aryeh.Stein{at}emory.edu


  Abstract

To study the role of nutrition in the association of birth size and childhood growth with development of cardiovascular disease, the authors in 2002-2004 surveyed 665 men and 790 women aged 25-42 years who had been exposed as children to a community-randomized nutrition supplementation intervention in four villages in eastern Guatemala. Exposure was associated with a lower fasting glucose level (7.0 mg/dl, 95% confidence interval (CI): 0.5, 13.5) for exposure at ages 36-72 months; lower systolic blood pressure (3.0 mmHg, 95% CI: 0.4, 5.6) for exposure at ages 24-60 months; and a lower triglyceride level (sex-adjusted; 22.2 mg/dl, 95% CI: 0.4, 44.1) and higher high density lipoprotein cholesterol level (males only; 4.7 mg/dl, 95% CI: 1.5, 7.9) for exposure prior to age 36 months. Improved nutrition at any age prior to 7 years was not associated with diastolic blood pressure, total or low density lipoprotein cholesterol level, or prevalence of the metabolic syndrome. Interventions designed to address nutrient deficiencies and ameliorate stunting that are targeted at pregnant women and young children are unlikely to increase cardiovascular disease risk later in life and may instead lower the risk.

Keywords: cardiovascular diseases; dietary supplements; intervention studies; nutrition.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Am. J. Clin. Nutr.Home page
J. G Ayer, J. A Harmer, W. Xuan, B. Toelle, K. Webb, C. Almqvist, G. B Marks, and D. S Celermajer
Dietary supplementation with n-3 polyunsaturated fatty acids in early childhood: effects on blood pressure and arterial structure and function at age 8 y
Am. J. Clinical Nutrition, August 1, 2009; 90(2): 438 - 446.
[Abstract] [Full Text] [PDF]

Home page
 Int J EpidemiolHome page
C. Fall
Commentary: Can improving a mother's diet improve her children's cardiovascular health?
Int. J. Epidemiol., February 1, 2009; 38(1): 127 - 128.
[Full Text] [PDF]

Home page
 Diabetes CareHome page
C. H.D. Fall, H. S. Sachdev, C. Osmond, R. Lakshmy, S. D. Biswas, D. Prabhakaran, N. Tandon, S. Ramji, K. S. Reddy, D. J.P. Barker, et al.
Adult Metabolic Syndrome and Impaired Glucose Tolerance Are Associated With Different Patterns of BMI Gain During Infancy: Data from the New Delhi birth cohort
Diabetes Care, December 1, 2008; 31(12): 2349 - 2356.
[Abstract] [Full Text] [PDF]

Home page
 Int J EpidemiolHome page
A. D Stein, P. Melgar, J. Hoddinott, and R. Martorell
Cohort Profile: The Institute of Nutrition of Central America and Panama (INCAP) Nutrition Trial Cohort Study
Int. J. Epidemiol., August 1, 2008; 37(4): 716 - 720.
[Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.