Skip Navigation



American Journal of Epidemiology Advance Access published online on September 25, 2006
American Journal of Epidemiology, doi:10.1093/aje/kwj321
This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
164/11/1027    most recent
kwj321v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Raimondi, S.
Right arrow Articles by Taioli, E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Raimondi, S.
Right arrow Articles by Taioli, E.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

American Journal of Epidemiology Copyright © 2006 by the Johns Hopkins Bloomberg School of Public Health All rights reserved; printed in U.S.A.
Received July 20, 2005
Accepted April 1, 2006

HUMAN GENOME EPIDEMIOLOGY (HuGE) REVIEW

Meta- and Pooled Analysis of GSTT1 and Lung Cancer: A Huge-GSEC Review

S. Raimondi 1, V. Paracchini 1, H. Autrup 2, J. M. Barros-Dios 3, S. Benhamou 4, P. Boffetta 5, M. L. Cote 6, I. A. Dialyna 7, V. Dolzan 8, R. Filiberti 9, S. Garte 10, A. Hirvonen 11, K. Husgafvel-Pursiainen 11, E. N. Imyanitov 12, I. Kalina 13, D. Kang 14, C. Kiyohara 15, T. Kohno 16, P. Kremers 17, Q. Lan 18, S. London 19, A. C. Povey 20, A. Rannug 21, E. Reszka 22, A. Risch 23, M. Romkes 24, J. Schneider 25, A. Seow 26, P. G. Shields 27, R. C. Sobti 28, M. Sørensen 29, M. Spinola 30, M. R. Spitz 31, R. C. Strange 32, I. Stücker 33, H. Sugimura 34, J. To-Figueras 35, S. Tokudome 36, P. Yang 37, J-M. Yuan 38, M. Warholm 21, and E. Taioli 24 *

1 Policlinico Milano, Milan, Italy
2 Institute of Public Health, University of Aarhus, Aarhus, Denmark
3 Department of Preventive Medicine and Public Health, University of Santiago de Compostela, Santiago de Compostela, Spain
4 INSERM and Evry University, Evry, France
5 Genetics and Epidemiology Cluster, International Agency for Research on Cancer, Lyon, France
6 Karmanos Cancer Institute, Wayne State University, Detroit, MI
7 Department of Virology, University of Crete, Crete, Greece
8 Institute of Biochemistry, University of Ljubljana, Ljubljana, Slovenia
9 Department of Epidemiology and Biostatistics, National Cancer Research Institute, Genoa, Italy
10 Genetics Research Institute, Milan, Italy; Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA
11 Finnish Institute of Occupational Health, Helsinki, Finland
12 N. N. Petrov Institute of Oncology, St. Petersburg, Russia
13 Department of Medical Biology, School of Medicine, P. J. Safárik University, Kosice, Slovakia
14 Institute of Environmental Medicine, Seoul National University, Seoul, Korea
15 Department of Preventive Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
16 Biology Division, National Cancer Center Research Institute, Tokyo, Japan
17 Service of Medical Chemistry, Institute of Pathology, Sart Tilman Liège, Belgium
18 Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD
19 National Institute for Environmental Health Sciences, Research Triangle Park, NC
20 Centre for Occupational and Environmental Health, University of Manchester, Manchester, United Kingdom
21 Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
22 Department of Toxicology and Carcinogenesis, Institute of Occupational Medicine, Lodz, Poland
23 Department of Toxicology and Cancer Risk Factors, DKFZ-German Cancer Research Center, Heidelberg, Germany
24 Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA
25 Institute of Occupational and Social Medicine, University of Giessen, Giessen, Germany
26 Department of Community, Occupational and Family Medicine, National University of Singapore, Singapore
27 Cancer Genetics and Epidemiology, Georgetown University Medical Center, Washington, DC
28 Department of Biotechnology, Panjab University, Chandigarh, India
29 Danish Cancer Society, Institute of Cancer Epidemiology, Copenhagen, Denmark
30 Department of Experimental Oncology, Istituto Nazionale Tumori, Milan, Italy
31 Department of Epidemiology, The University of Texas, M. D. Anderson Cancer Center, Houston, TX
32 Centre for Cell and Molecular Medicine, Keele University, North Staffordshire Hospital, Staffordshire, England
33 INSERM Unit of Epidemiologic Statistic Research on the Environment and Health, Villejuif Cedex, France
34 First Department of Pathology, Hamamatsu University School of Medicine, Hamamatsu, Japan
35 Hospital Clinic Provincial Toxicology Unit, Barcelona, Spain
36 Department of Health Promotion and Preventive Medicine, Nagoya City University Graduate School of Medical Sciences, Mizuho-ku, Nagoya, Japan
37 Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN
38 School of Public Health, University of Minnesota, Minneapolis, MN

* To whom correspondence should be addressed.
E. Taioli, E-mail: taiolien{at}upmc.edu


  Abstract

Lung cancer is the most common malignancy in the Western world, and the main risk factor is tobacco smoking. Polymorphisms in metabolic genes may modulate the risk associated with environmental factors. The glutathione S-transferase theta 1 gene (GSTT1) is a particularly attractive candidate for lung cancer susceptibility because of its involvement in the metabolism of polycyclic aromatic hydrocarbons found in tobacco smoke and of other chemicals, pesticides, and industrial solvents. The frequency of the GSTT1 null genotype is lower among Caucasians (10-20%) than among Asians (50-60%). The authors present a meta- and a pooled analysis of case-control, genotype-based studies that examined the association between GSTT1 and lung cancer (34 studies, 7,629 cases and 10,087 controls for the meta-analysis; 34 studies, 7,044 cases and 10,000 controls for the pooled analysis). No association was observed between GSTT1 deletion and lung cancer for Caucasians (odds ratio (OR) = 0.99, 95% confidence interval (CI): 0.87, 1.12); for Asians, a positive association was found (OR = 1.28, 95% CI: 1.10, 1.49). In the pooled analysis, the odds ratios were not significant for either Asians (OR = 0.97, 95% CI: 0.83, 1.13) or Caucasians (OR = 1.09, 95% CI: 0.99, 1.21). No significant interaction was observed between GSTT1 and smoking on lung cancer, whereas GSTT1 appeared to modulate occupational-related lung cancer.

Keywords: disease susceptibility; epidemiology; genes; genetic predisposition to disease; GSTT1; lung neoplasms; meta-analysis.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Clin. Cancer Res.Home page
C. M. Rudin, E. Avila-Tang, C. C. Harris, J. G. Herman, F. R. Hirsch, W. Pao, A. G. Schwartz, K. H. Vahakangas, and J. M. Samet
Lung Cancer in Never Smokers: Molecular Profiles and Therapeutic Implications
Clin. Cancer Res., September 15, 2009; 15(18): 5646 - 5661.
[Abstract] [Full Text] [PDF]

Home page
 Vet PatholHome page
A. K. Bauer and E. A. Rondini
REVIEW PAPER: The Role of Inflammation in Mouse Pulmonary Neoplasia
Vet. Pathol., May 1, 2009; 46(3): 369 - 390.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
M. L. Cote, W. Yoo, A. S. Wenzlaff, G. M. Prysak, S. K. Santer, G. B. Claeys, A. L. Van Dyke, S. J. Land, and A. G. Schwartz
Tobacco and estrogen metabolic polymorphisms and risk of non-small cell lung cancer in women
Carcinogenesis, April 1, 2009; 30(4): 626 - 635.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
W. D. Foulkes
Inherited Susceptibility to Common Cancers
N. Engl. J. Med., November 13, 2008; 359(20): 2143 - 2153.
[Full Text] [PDF]

Home page
 CarcinogenesisHome page
E. Taioli
Gene-environment interaction in tobacco-related cancers
Carcinogenesis, August 1, 2008; 29(8): 1467 - 1474.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
D. W. Bell, B. W. Brannigan, K. Matsuo, D. M. Finkelstein, R. Sordella, J. Settleman, T. Mitsudomi, and D. A. Haber
Increased Prevalence of EGFR-Mutant Lung Cancer in Women and in East Asian Populations: Analysis of Estrogen-Related Polymorphisms
Clin. Cancer Res., July 1, 2008; 14(13): 4079 - 4084.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
N. S. Weiss
Subgroup-Specific Associations in the Face of Overall Null Results: Should We Rush In or Fear to Tread?
Cancer Epidemiol. Biomarkers Prev., June 1, 2008; 17(6): 1297 - 1299.
[Full Text] [PDF]

Home page
 JAMAHome page
L. M. Dong, J. D. Potter, E. White, C. M. Ulrich, L. R. Cardon, and U. Peters
Genetic Susceptibility to Cancer: The Role of Polymorphisms in Candidate Genes
JAMA, May 28, 2008; 299(20): 2423 - 2436.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
K.-M. Lee, D. Kang, M. L. Clapper, M. Ingelman-Sundberg, M. Ono-Kihara, C. Kiyohara, S. Min, Q. Lan, L. Le Marchand, P. Lin, et al.
CYP1A1, GSTM1, and GSTT1 Polymorphisms, Smoking, and Lung Cancer Risk in a Pooled Analysis among Asian Populations
Cancer Epidemiol. Biomarkers Prev., May 1, 2008; 17(5): 1120 - 1126.
[Abstract] [Full Text] [PDF]

Home page
 Am J EpidemiolHome page
C. Carlsten, G. S. Sagoo, A. J. Frodsham, W. Burke, and J. P. T. Higgins
Glutathione S-Transferase M1 (GSTM1) Polymorphisms and Lung Cancer: A Literature-based Systematic HuGE Review and Meta-Analysis
Am. J. Epidemiol., April 1, 2008; 167(7): 759 - 774.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
A. Rossini, D.C.M. Rapozo, S.C. Soares Lima, D.P. Guimaraes, M.A. Ferreira, R. Teixeira, C.D.P. Kruel, S.G.S. Barros, N.A. Andreollo, R. Acatauassu, et al.
Polymorphisms of GSTP1 and GSTT1, but not of CYP2A6, CYP2E1 or GSTM1, modify the risk for esophageal cancer in a western population
Carcinogenesis, December 1, 2007; 28(12): 2537 - 2542.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
P. Vineis, S. Anttila, S. Benhamou, M. Spinola, A. Hirvonen, C. Kiyohara, S. J. Garte, R. Puntoni, A. Rannug, R. C. Strange, et al.
Evidence of gene gene interactions in lung carcinogenesis in a large pooled analysis
Carcinogenesis, September 1, 2007; 28(9): 1902 - 1905.
[Abstract] [Full Text] [PDF]

Home page
 Am J EpidemiolHome page
RE: "META- AND POOLED ANALYSIS OF GSTT1 AND LUNG CANCER: A HUGE-GSEC REVIEW"
Am. J. Epidemiol., August 1, 2007; 166(3): 366 - 366.
[Full Text] [PDF]

Home page
 Am J EpidemiolHome page
N. S. Weiss
RE: "META- AND POOLED ANALYSIS OF GSTT1 AND LUNG CANCER: A HuGE-GSEC REVIEW"
Am. J. Epidemiol., June 15, 2007; 165(12): 1462 - 1462.
[Full Text] [PDF]

Home page
 Am J EpidemiolHome page
E. Taioli
AN AUTHOR REPLIES
Am. J. Epidemiol., June 15, 2007; 165(12): 1462 - 1463.
[Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.