Skip Navigation



American Journal of Epidemiology Advance Access published online on June 7, 2006
American Journal of Epidemiology, doi:10.1093/aje/kwj203
This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
164/3/212    most recent
kwj203v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Alderton, L. E.
Right arrow Articles by Ross, J. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Alderton, L. E.
Right arrow Articles by Ross, J. A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

American Journal of Epidemiology Copyright © 2006 by the Johns Hopkins Bloomberg School of Public Health All rights reserved; printed in U.S.A.
Received September 7, 2005
Accepted February 17, 2006

ORIGINAL CONTRIBUTIONS

Child and Maternal Household Chemical Exposure and the Risk of Acute Leukemia in Children with Down's Syndrome: A Report from the Children's Oncology Group

Lucy E. Alderton 1, Logan G. Spector 2 *, Cindy K. Blair 2, Michelle Roesler 2, Andrew F. Olshan 3, Leslie L. Robison 2, and Julie A. Ross 2

1 Division of Epidemiology, University of Minnesota School of Public Health, Minneapolis, MN; Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN
2 Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN; University of Minnesota Cancer Center, Minneapolis, MN
3 Department of Epidemiology, University of North Carolina, Chapel Hill, NC

* To whom correspondence should be addressed.
Logan G. Spector, E-mail: spector{at}epi.umn.edu


  Abstract

Compared with the general pediatric population, children with Down's syndrome have a much higher risk of acute leukemia. This case-control study was designed to explore potential risk factors for acute lymphoblastic leukemia and acute myeloid leukemia in children with Down's syndrome living in the United States or Canada. Mothers of 158 children with Down's syndrome and acute leukemia (97 acute lymphoblastic leukemia, 61 acute myeloid leukemia) diagnosed between January 1997 and October 2002 and mothers of 173 children with Down's syndrome but without leukemia were interviewed by telephone. Positive associations were found between acute lymphoblastic leukemia and maternal exposure to professional pest exterminations (odds ratio = 2.25, 95% confidence interval: 1.13, 4.49), to any pesticide (odds ratio = 2.18, 95% confidence interval: 1.08, 4.39), and to any chemical (odds ratio = 2.72, 95% confidence interval: 1.17, 6.35). Most of the associations with acute myeloid leukemia were nonsignificant, and odds ratios were generally near or below 1.0. This exploratory study suggests that household chemical exposure may play a role in the development of acute lymphoblastic leukemia in children with Down's syndrome.

Keywords: Down syndrome; environmental exposure; leukemia; maternal exposure.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 The OncologistHome page
K. R. Rabin and J. A. Whitlock
Malignancy in Children with Trisomy 21
Oncologist, February 1, 2009; 14(2): 164 - 173.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.