American Journal of Epidemiology Advance Access published online on March 22, 2006
American Journal of Epidemiology, doi:10.1093/aje/kwj128
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1 Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA; Department of Epidemiology, Harvard School of Public Health, Boston, MA
* To whom correspondence should be addressed. Assessments of the relation between folate intake and ovarian cancer risk have been limited and inconsistent. Therefore, the authors prospectively examined the association of dietary and supplemental intakes of folate, methionine, and vitamin B6 with ovarian cancer risk among 80,254 Nurses' Health Study participants. Beginning in 1976, women completed biennial questionnaires assessing ovarian cancer risk factors; starting in 1980, food frequency questionnaires were administered every 2-4 years. During 22 years of follow-up (1980-2002), the authors confirmed 481 incident epithelial ovarian cancers. There were no associations between total folate (top quintile vs. bottom: relative risk (RR) = 1.21, 95% confidence interval (CI): 0.92, 1.60), methionine (RR = 1.00, 95% CI: 0.76, 1.33), dietary vitamin B6 (RR = 1.09, 95% CI: 0.81, 1.47), or total vitamin B6 (RR = 1.13, 95% CI: 0.85, 1.51) intake and ovarian cancer risk. Higher dietary folate was associated with a modestly decreased risk after exclusion of cases diagnosed during the 4 follow-up years after dietary assessment (RR = 0.66, 95% CI: 0.43, 1.03) and for the serous subtype (RR = 0.51, 95% CI: 0.31, 0.84). Results did not vary by alcohol intake, multivitamin use, menopausal status, or oral contraceptive use. There was little evidence that folate, methionine, and vitamin B6 are important in ovarian cancer risk, although dietary folate was inversely associated with risk in some analyses.
Received July 15, 2005
Accepted December 28, 2005
ORIGINAL CONTRIBUTIONS
Intake of Folate and Related Nutrients in Relation to Risk of Epithelial Ovarian Cancer
Shelley S. Tworoger 1 *,
Jonathan L. Hecht 2,
Edward Giovannucci 3,
and
Susan E. Hankinson 1
2 Department of Pathology, Beth-Israel Deaconess Medical Center, Boston, MA
3 Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA; Department of Epidemiology, Harvard School of Public Health, Boston, MA; Department of Nutrition, Harvard School of Public Health, Boston, MA
Shelley S. Tworoger, E-mail: nhsst{at}channing.harvard.edu
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