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American Journal of Epidemiology Advance Access published online on March 1, 2006
American Journal of Epidemiology, doi:10.1093/aje/kwj104
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American Journal of Epidemiology Copyright © 2006 by the Johns Hopkins Bloomberg School of Public Health All rights reserved; printed in U.S.A.
Received September 7, 2005
Accepted December 13, 2005

ORIGINAL CONTRIBUTIONS

Maternal and Infant Birth Characteristics and Hepatoblastoma

Colleen C. McLaughlin 1 *, Mark S. Baptiste 2, Maria J. Schymura 1, Philip C. Nasca 3, and Michael S. Zdeb 4

1 New York State Cancer Registry, New York State Department of Health, Albany, NY; School of Public Health, State University of New York at Albany, Albany, NY
2 School of Public Health, State University of New York at Albany, Albany, NY; Division of Chronic Disease Prevention and Adult Health, New York State Department of Health, Albany, NY
3 School of Public Health and Health Sciences, University of Massachusetts at Amherst, Amherst, MA
4 School of Public Health, State University of New York at Albany, Albany, NY

* To whom correspondence should be addressed.
Colleen C. McLaughlin, E-mail: ccm01{at}health.state.ny.us


  Abstract

Hepatoblastoma is a rare embryonal tumor with unknown etiology. The authors conducted a case-cohort study using public health surveillance data sets to examine perinatal risk factors for hepatoblastoma. Hepatoblastoma cases (n = 58) diagnosed between 1985 and 2001 were identified from the New York State Cancer Registry and were matched to electronic birth records for 1985-2001 from New York State, excluding New York City. Controls (n = 6,056) were selected from the birth cohorts for the same years. Having a birth weight less than 1,000 g was associated with a strongly increased risk of hepatoblastoma (relative risk (RR) = 56.9, 95% confidence interval (CI): 24.0, 130.7). After adjustment for birth weight, a moderately increased risk of hepatoblastoma was found for younger maternal age (<20 years vs. 20-29 years: RR = 2.5, 95% CI: 1.0, 5.5), presumptive use of infertility treatment (RR = 9.2, 95% CI: 2.1, 31.5), maternal smoking (RR = 2.1, 95% CI: 1.0, 4.2), and higher maternal prepregnancy body mass index (body mass index of 25-29 vs. 20-24: RR = 2.9, 95% CI: 1.2, 7.6).

Keywords: hepatoblastoma; infant, very low birth weight; maternal age; maternal welfare; reproductive techniques, assisted.
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