Skip Navigation



American Journal of Epidemiology Advance Access published online on February 22, 2006
American Journal of Epidemiology, doi:10.1093/aje/kwj098
This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
163/8/709    most recent
kwj098v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Patel, A. V.
Right arrow Articles by Calle, E. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Patel, A. V.
Right arrow Articles by Calle, E. E.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

American Journal of Epidemiology Copyright © 2006 by the Johns Hopkins Bloomberg School of Public Health All rights reserved; printed in U.S.A.
Received July 22, 2005
Accepted December 5, 2005

ORIGINAL CONTRIBUTIONS

Recreational Physical Activity and Sedentary Behavior in Relation to Ovarian Cancer Risk in a Large Cohort of US Women

Alpa V. Patel 1 *, Carmen Rodriguez 1, Alexandre L. Pavluck 1, Michael J. Thun 1, and Eugenia E. Calle 1

1 From the Department of Epidemiology and Surveillance Research, American Cancer Society, Atlanta, GA

* To whom correspondence should be addressed.
Alpa V. Patel, E-mail: apatel{at}cancer.org


  Abstract

Factors that influence circulating sex hormones, such as physical activity, have been proposed to influence ovarian cancer risk; however, results from previous epidemiologic studies have been inconsistent. The authors examined the association among physical activity, sedentary behavior, and ovarian cancer risk in the American Cancer Society Cancer Prevention Study II Nutrition Cohort, a prospective study of cancer incidence and mortality, using information obtained at baseline in 1992. From 1992 to 2001, 314 incident ovarian cancer cases were identified among 59,695 postmenopausal women who were cancer free at enrollment. Cox proportional hazards modeling was used to compute hazard rate ratios while adjusting for potential confounders. No overall association was observed between measures of past physical activity or with recreational physical activity at baseline and risk of ovarian cancer in this study (for the highest category of physical activity compared with none: hazard rate ratio = 0.73, 95% confidence interval: 0.40, 1.34). However, a prolonged duration of sedentary behavior was associated with an increased risk (for ≥6 vs. <3 hours per day: hazard rate ratio = 1.55, 95% confidence interval: 1.08, 2.22; ptrend = 0.01). Results from this study suggest that high levels of sedentary behavior may increase the risk of ovarian cancer, but they do not support a major impact of light and moderate physical activity on ovarian cancer risk.

Keywords: cohort studies; exercise; ovarian neoplasms.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Am J EpidemiolHome page
E. R. Bertone-Johnson, S. S. Tworoger, and S. E. Hankinson
Recreational Physical Activity and Steroid Hormone Levels in Postmenopausal Women
Am. J. Epidemiol., November 1, 2009; 170(9): 1095 - 1104.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
C. B. Ambrosone
Eugenia Calle: In Memoriam (1952-2009)
Cancer Res., April 1, 2009; 69(7): 3238 - 3239.
[Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
P. H. Lahmann, C. Friedenreich, M. Schulz, A. E. Cust, A. Lukanova, R. Kaaks, A. Tjonneland, N. F. Johnsen, K. Overvad, A. Fournier, et al.
Physical Activity and Ovarian Cancer Risk: the European Prospective Investigation into Cancer and Nutrition
Cancer Epidemiol. Biomarkers Prev., January 1, 2009; 18(1): 351 - 354.
[Full Text] [PDF]

Home page
 aacredbookHome page
L. Bernstein
Physical Activity and Cancer
Am. Assoc. Cancer Res. Educ. Book, April 12, 2008; 2008(1): 225 - 231.
[Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
C. M. Olsen, C. J. Bain, S. J. Jordan, C. M. Nagle, A. C. Green, D. C. Whiteman, P. M. Webb, and Australian Cancer Study (Ovarian Cancer) and Austr
Recreational Physical Activity and Epithelial Ovarian Cancer: A Case-Control Study, Systematic Review, and Meta-analysis
Cancer Epidemiol. Biomarkers Prev., November 1, 2007; 16(11): 2321 - 2330.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.