American Journal of Epidemiology Advance Access published online on February 22, 2006
American Journal of Epidemiology, doi:10.1093/aje/kwj097
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1 Department of Social and Preventive Medicine, State University of New York at Buffalo, Buffalo, NY
* To whom correspondence should be addressed. Despite the documented antioxidant and chemopreventive properties of selenium, studies of selenium intake and supplementation and cardiovascular disease have yielded inconsistent findings. The authors examined the effect of selenium supplementation (200 µg daily) on cardiovascular disease incidence and mortality through the entire blinded phase of the Nutritional Prevention of Cancer Trial (1983-1996) among participants who were free of cardiovascular disease at baseline (randomized to selenium: n = 504; randomized to placebo: n = 500). Selenium supplementation was not significantly associated with any of the cardiovascular disease endpoints during 7.6 years of follow-up (all cardiovascular disease: hazard ratio (HR) = 1.03, 95% confidence interval (CI): 0.78, 1.37; myocardial infarction: HR = 0.94, 95% CI: 0.61, 1.44; stroke: HR = 1.02, 95% CI: 0.63, 1.65; all cardiovascular disease mortality: HR = 1.22, 95% CI: 0.76, 1.95). The lack of significant association with cardiovascular disease endpoints was also confirmed when analyses were further stratified by tertiles of baseline plasma selenium concentrations. These findings indicate no overall effect of selenium supplementation on the primary prevention of cardiovascular disease in this population.
Received September 16, 2005
Accepted November 29, 2005
ORIGINAL CONTRIBUTIONS
Effects of Selenium Supplementation on Cardiovascular Disease Incidence and Mortality: Secondary Analyses in a Randomized Clinical Trial
Saverio Stranges 1 *,
James R. Marshall 2,
Maurizio Trevisan 1,
Raj Natarajan 2,
Richard P. Donahue 1,
Gerald F. Combs 3,
Eduardo Farinaro 4,
Larry C. Clark 
,
and
Mary E. Reid 2
2 Cancer Prevention and Population Sciences, Roswell Park Cancer Institute, Buffalo, NY
3 US Department of Agriculture Human Nutrition Research Center, Grand Forks, ND
4 Department of Preventive Medical Sciences, "Federico II" University of Naples Medical School, Naples, Italy
Saverio Stranges, E-mail: stranges{at}buffalo.edu
Abstract Deceased.
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