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American Journal of Epidemiology Advance Access published online on February 8, 2006
American Journal of Epidemiology, doi:10.1093/aje/kwj070
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American Journal of Epidemiology Copyright © 2006 by the Johns Hopkins Bloomberg School of Public Health All rights reserved; printed in U.S.A.
Received April 1, 2005
Accepted October 27, 2005

ORIGINAL CONTRIBUTIONS

Oral Polio Vaccine and Intussusception: A Data Linkage Study using Records for Vaccination and Hospitalization

J. Claire Cameron 1 *, David Walsh 2, Alan R. Finlayson 3, and James H. Boyd 3

1 Health Protection Scotland, Glasgow, United Kingdom
2 Health Scotland, Glasgow, United Kingdom
3 ISD Scotland, Edinburgh, United Kingdom

* To whom correspondence should be addressed.
J. Claire Cameron, E-mail: claire.cameron{at}hps.scot.nhs.uk


  Abstract

The authors investigated the possibility of an association between oral polio vaccine (OPV) and intussusception by linking Scottish vaccination and hospitalization data sets and performing self-controlled case series analysis. The issue was important because rotavirus vaccine, another live oral virus vaccine, was withdrawn from the market in 1999 after studies showed a strong association with intussusception. OPV was recommended for all infants in the United Kingdom at ages 2, 3, and 4 months until 2004, when new combination vaccines containing inactivated poliovirus were introduced. Analysis was carried out for 466 intussusception cases occurring in 1987-1999 for which linked records on OPV vaccination were available. Six possible risk periods for intussusception, ranging from 3 days after vaccination to 41 days after vaccination, were examined, with separate analysis for each of the three OPV doses and also for data on all three doses combined. Of the 24 possible risk periods examined, the relative incidence of intussusception after vaccination was unchanged for 18, significantly decreased for five, and significantly increased for only one. The authors conclude that overall, there is no evidence for an association between OPV and intussusception, even when each dose is considered separately.

Keywords: intussusception; medical record linkage; poliovirus vaccines.
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