American Journal of Epidemiology Advance Access published online on December 7, 2005
American Journal of Epidemiology, doi:10.1093/aje/kwj017
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1 Department of Medicine, Center for Health Services Research, Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, TN; Department of Epidemiology, School of Public Health, University of California at Los Angeles, Los Angeles, CA
* To whom correspondence should be addressed. The authors investigated the association between overweight at the time of or soon after cancer diagnosis and survival in a cohort of 1,455 breast cancer patients aged 25-64 years. The patients were recruited into the Shanghai Breast Cancer Study (Shanghai, China), a population-based case-control study, between August 1996 and March 1998. The median follow-up time for this cohort was 5.1 years (1996-2002) after breast cancer diagnosis, and 240 deaths were identified. Being overweight at cancer diagnosis or soon afterward, as measured by body mass index (BMI; weight (kg)/height (m)2), was associated with poorer overall survival and disease-free survival. Five-year survival rates were 86.5%, 83.8%, and 80.1% for subjects whose BMIs were <23.0, 23.0-24.9, and
Received May 13, 2005
Accepted August 19, 2005
ORIGINAL CONTRIBUTIONS
Association of Overweight with Breast Cancer Survival
Meng-Hua Tao 1,
Xiao-Ou Shu 2 *,
Zhi Xian Ruan 3,
Yu-Tang Gao 3,
and
Wei Zheng 2
2 Department of Medicine, Center for Health Services Research, Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, TN
3 Department of Epidemiology, Shanghai Cancer Institute, Shanghai, China
Xiao-Ou Shu, E-mail: Xiao-Ou.Shu{at}Vanderbilt.edu
Abstract 
25.0, respectively (p = 0.02); the corresponding 5-year disease-free survival rates were 81.9%, 78.1%, and 76.6% (p = 0.05). The inverse association between BMI and survival persisted after adjustment for age at diagnosis and other known prognostic factors for breast cancer, including disease stage. The authors found neither waist:hip ratio nor waist circumference to be independently associated with overall survival or disease-free survival. These results suggest that excess weight may be an independent predictor of breast cancer survival among Chinese women.
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