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American Journal of Epidemiology Advance Access published online on November 3, 2005
American Journal of Epidemiology, doi:10.1093/aje/kwi339
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American Journal of Epidemiology Copyright © 2005 by the Johns Hopkins Bloomberg School of Public Health All rights reserved; printed in U.S.A.
Received February 7, 2005
Accepted July 22, 2005

ORIGINAL CONTRIBUTIONS

Oxidative Stress and Pulmonary Function in the General Population

Heather M. Ochs-Balcom 1, Brydon J. B. Grant 2, Paola Muti 3, Christopher T. Sempos 4, Jo L. Freudenheim 4, Richard W. Browne 5, Maurizio Trevisan 4, Licia Iacoviello 6, Patricia A. Cassano 7, and Holger J. Schünemann 8*

1 Department of Social and Preventive Medicine, School of Public Health and Health Professions, University at Buffalo, Buffalo, NY; Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH; Ireland Comprehensive Cancer Center at University Hospitals of Cleveland and Case Western Reserve University, Cleveland, OH
2 Department of Social and Preventive Medicine, School of Public Health and Health Professions, University at Buffalo, Buffalo, NY; Section of Pulmonary, Critical Care, and Sleep Medicine, Veterans Administration Medical Center, Buffalo, NY; Department of Medicine, School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY
3 Department of Social and Preventive Medicine, School of Public Health and Health Professions, University at Buffalo, Buffalo, NY; Department of Epidemiology, Italian National Cancer Institute Regina Elena, Rome, Italy
4 Department of Social and Preventive Medicine, School of Public Health and Health Professions, University at Buffalo, Buffalo, NY
5 Department of Clinical Laboratory Science, School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY
6 Center for High Technology Research and Education in Biomedical Sciences, Catholic University, Campobosso, Italy
7 Division of Nutritional Sciences, Cornell University, Ithaca, NY
8 Department of Social and Preventive Medicine, School of Public Health and Health Professions, University at Buffalo, Buffalo, NY; Department of Medicine, School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY; Department of Epidemiology, Italian National Cancer Institute Regina Elena, Rome, Italy; Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada

* To whom correspondence should be addressed.
Holger J. Schünemann, E-mail: schuneh{at}mcmaster.ca


  Abstract

Studies have shown increased oxidative stress in patients with chronic airflow limitation; however, the population-based evidence for the association of oxidative stress with pulmonary function is limited. The authors analyzed the association of plasma thiobarbituric acid-reactive substances (TBARS), glutathione, glutathione peroxidase, and 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid (Trolox)-equivalent antioxidant capacity with forced expiratory volume in 1 second and forced vital capacity using data collected from 1996 to 2000 in a general population sample from western New York State (n = 2,346). After adjustment for covariates including smoking status, lifetime pack-years of smoking, education, weight, and eosinophils, multivariate analysis showed an inverse association of TBARS with forced expiratory volume in 1 second and forced vital capacity as the percentage of the predicted value (FEV1% and FVC%, respectively), positive associations of glutathione peroxidase with FEV1% and FVC%, and an inverse association of glutathione with FEV1% in men (p < 0.05). The associations of TBARS and glutathione peroxidase with FVC% in men remained statistically significant after adjustment for serum carotenoid levels. There were no statistically significant associations of oxidative stress with pulmonary function in women. These results suggest that oxidative stress may be associated with airflow limitation in men, and that gender differences may exist in the relation of oxidative stress to pulmonary function.

Keywords: forced expiratory volume; glutathione; glutathione peroxidase; oxidative stress; respiratory function tests; thiobarbituric acid reactive substances; vital capacity.
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