American Journal of Epidemiology Advance Access published online on September 21, 2005
American Journal of Epidemiology, doi:10.1093/aje/kwi284
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 Cancer Epidemiology and Registration Unit, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), Institut Català d'Oncologia, L'Hospitalet de Llobregat, Barcelona, Spain
* To whom correspondence should be addressed. Male circumcision has been shown to reduce the risk of acquiring and transmitting a number of venereal infections. However, little is known about the association between male circumcision and the risk of Chlamydia trachomatis infection in the female partner. The authors pooled data on 305 adult couples enrolled as controls in one of five case-control studies of invasive cervical cancer conducted in Thailand, the Philippines, Brazil, Colombia, and Spain between 1985 and 1997. Women provided blood samples for C. trachomatis and Chlamydia pneumoniae antibody detection; a type-specific microfluorescence assay was used. Multivariate odds ratios were computed for the association between male circumcision status and chlamydial seropositivity in women. Compared with women with uncircumcised partners, those with circumcised partners had a 5.6-fold reduced risk of testing seropositive for C. trachomatis (82% reduction; odds ratio = 0.18, 95% confidence interval: 0.05, 0.58). The inverse association was also observed after restricting the analysis to monogamous women and their only male partners (odds ratio = 0.21, 95% confidence interval: 0.06, 0.72). In contrast, seropositivity to C. pneumoniae, a non-sexually-transmitted infection, was not significantly related to circumcision status of the male partner. These findings suggest that male circumcision could reduce the risk of C. trachomatis infection in female sexual partners.
Received February 13, 2005
Accepted May 25, 2005
ORIGINAL CONTRIBUTIONS
Chlamydia trachomatis Infection in Female Partners of Circumcised and Uncircumcised Adult Men
2 National Laboratory for Sexually Transmitted Diseases, Health Canada, Winnipeg, Canada
3 Epidemiology and Biology Cluster, International Agency for Research on Cancer, Lyon, France
4 Department of Epidemiology, University of North Carolina, Chapel Hill, NC
5 Instituto Costarricense de Investigación y Enseñanza en Nutrición y Salud (INCIENSA), San José, Costa Rica
Xavier Castellsagué, E-mail: xcastellsague{at}ico.scs.es
Abstract 
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  J Sobngwi-Tambekou, D Taljaard, M Nieuwoudt, P Lissouba, A Puren, and B Auvert Male circumcision and Neisseria gonorrhoeae, Chlamydia trachomatis and Trichomonas vaginalis: observations after a randomised controlled trial for HIV prevention Sex Transm Inf, April 1, 2009; 85(2): 116 - 120. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M-C Boily, K Desai, B Masse, and A Gumel Incremental role of male circumcision on a generalised HIV epidemic through its protective effect against other sexually transmitted infections: from efficacy to effectiveness to population-level impact Sex Transm Inf, October 1, 2008; 84(Suppl_2): ii28 - ii34. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Rennie, A. S Muula, and D. Westreich Male circumcision and HIV prevention: ethical, medical and public health tradeoffs in low-income countries J. Med. Ethics, June 1, 2007; 33(6): 357 - 361. [Full Text] [PDF]
|
|
|
|
 |
|
 D. M. Fergusson, J. M. Boden, and L. J. Horwood Circumcision Status and Risk of Sexually Transmitted Infection in Young Adult Males: An Analysis of a Longitudinal Birth Cohort Pediatrics, November 1, 2006; 118(5): 1971 - 1977. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. J. Schoen Ignoring Evidence of Circumcision Benefits Pediatrics, July 1, 2006; 118(1): 385 - 387. [Full Text] [PDF]
|
|