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American Journal of Epidemiology Advance Access published online on August 10, 2005
American Journal of Epidemiology, doi:10.1093/aje/kwi241
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American Journal of Epidemiology Copyright © 2005 by the Johns Hopkins Bloomberg School of Public Health All rights reserved
Received December 20, 2004
Accepted April 20, 2005

Article

Is the Risk of Lung Cancer Reduced among Eczema Patients?

Marine Castaing 1, Judith Youngson 2, David Zaridze 3, Neonila Szeszenia-Dabrowska 4, Peter Rudnai 5, Jolanta Lissowska 6, Eleonóra Fabiánová 7, Dana Mates 8, Vladimir Bencko 9, Lenka Foretova 10, Marie Navratilova 10, Vladimir Janout 11, Tony Fletcher 12, Paul Brennan 1, and Paolo Boffetta 1*

1 Gene-Environment Epidemiology Group, International Agency for Research on Cancer, Lyon, France
2 Department of Public Health, University of Liverpool, Liverpool, United Kingdom
3 Institute of Carcinogenesis, Cancer Research Center, Moscow, Russia
4 Department of Epidemiology, Nofer Institute of Occupational Medicine, Lodz, Poland
5 National Institute of Environmental Health, Budapest, Hungary
6 Cancer Center and Maria Sklodowska-Curie Institute of Oncology, Warsaw, Poland
7 Department of Occupational Health, Specialized State Health Institute, Banska Bystrica, Slovakia
8 Institute of Hygiene, Public Health, Health Services and Management, Bucharest, Romania
9 Republic Charles University in Prague, First Faculty of Medicine and General University Hospital, Institute of Hygiene and Epidemiology, Prague, Czech Republic
10 Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic
11 Department of Preventive Medicine, Faculty of Medicine, Palacky University, Olomouc, Czech Republic
12 Public and Environmental Health Research Unit, London School of Hygiene and Tropical Medicine, London, United Kingdom

* To whom correspondence should be addressed.
Paolo Boffetta, E-mail: boffetta{at}iarc.fr


  Abstract

Persons with a history of eczema have been shown to have a reduced risk of lung cancer, but the evidence has been inconclusive because of the small size of previous studies and their limited ability to control for confounding by smoking. The objective of this study was to determine the role of eczema in relation to lung cancer while overcoming the limitations of previous investigations. Study subjects included 2,854 cases and 3,116 population and hospital controls recruited during 1998-2001 from 16 areas in the Czech Republic, Hungary, Poland, Romania, Russia, Slovakia, and the United Kingdom. Odds ratios were calculated for self-reported history of eczema via multivariate logistic regression modeling. The odds ratio for a history of eczema was 0.61 (95% confidence interval: 0.48, 0.76) after control for age, sex, study center, and cumulative tobacco smoking. There was no heterogeneity in the results by sex or age at onset of eczema. Subjects reporting use of medication for eczema had a lower odds ratio than subjects not reporting such use. This study provides further evidence for an inverse association between history of eczema and lung cancer risk, which is unlikely to be due to chance, bias, or confounding.

Keywords: eczema; lung neoplasms.
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