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American Journal of Epidemiology Advance Access published online on August 10, 2005
American Journal of Epidemiology, doi:10.1093/aje/kwi237
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American Journal of Epidemiology Copyright © 2005 by the Johns Hopkins Bloomberg School of Public Health All rights reserved
Received October 18, 2004
Accepted April 19, 2005

Article

Helicobacter pylori and Overweight Status in the United States: Data from the Third National Health and Nutrition Examination Survey

Ilseung Cho 1, Martin J. Blaser 2, Fritz François 2, Jomol P. Mathew 3, Xiang Y. Ye 3, Judith D. Goldberg 3, and Edmund J. Bini 2*

1 Department of Medicine, New York University School of Medicine, New York, NY
2 Department of Medicine, New York University School of Medicine, New York, NY; VA New York Harbor Healthcare System, New York, NY
3 Division of Biostatistics, Department of Environmental Medicine, New York University School of Medicine, New York, NY

* To whom correspondence should be addressed.
Edmund J. Bini, E-mail: Edmund.Bini{at}med.va.gov


  Abstract

Obesity is an important public health problem in the United States. Because of its potential effects on gastric leptin homeostasis, Helicobacter pylori may play a role in regulating body weight. The authors' aim in this study was to examine the association between H. pylori colonization and overweight status. Nonpregnant participants in the Third National Health and Nutrition Examination Survey (1988-1994) aged ≥20 years who had had H. pylori testing performed and body mass index (weight (kg)/height (m)2) measured were studied. Overweight was defined as a body mass index greater than or equal to 25. On the basis of serologic results, the participants were categorized into three H. pylori status groups: H. pylori-positive and cytotoxin-associated gene A (cagA)-positive (H. pylori+cagA+), H. pylori-positive and cagA-negative (H. pylori+cagA-), and H. pylori-negative (H. pylori-). Of the 7,003 subjects with complete body mass index and H. pylori data, 2,634 (weighted percentage, 22.9%) were H. pylori+cagA+, 1,385 (15.1%) were H. pylori+cagA-, and 2,984 (62.0%) were H. pylori-. The adjusted odds of being overweight were 1.17 (95% confidence interval: 0.98, 1.39; p = 0.075) for the H. pylori+cagA+ group and 0.99 (95% confidence interval: 0.80, 1.22; p = 0.92) for the H. pylori+cagA- group in comparison with H. pylori- subjects. Serum leptin levels did not differ significantly between the three H. pylori groups. In this US population-based study, there was no significant association between H. pylori colonization, cagA+ strains of H. pylori, and being overweight.

Keywords: body mass index; body weight; cagA protein, Helicobacter pylori; Helicobacter pylori; obesity.
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