Skip Navigation



American Journal of Epidemiology Advance Access published online on June 22, 2005
American Journal of Epidemiology, doi:10.1093/aje/kwi174
This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
162/2/101    most recent
kwi174v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Paracchini, V.
Right arrow Articles by Taioli, E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Paracchini, V.
Right arrow Articles by Taioli, E.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

American Journal of Epidemiology Copyright © 2005 by the Johns Hopkins Bloomberg School of Public Health All rights reserved
Received November 30, 2004
Accepted March 7, 2005

HUMAN GENOME EPIDEMIOLOGY (HuGE) REVIEW

Genetics of Leptin and Obesity: A HuGE Review

Valentina Paracchini 1, Paola Pedotti 1, and Emanuela Taioli 1*

1 From the Unit of Molecular and Genetic Epidemiology, Fondazione Policlinico IRCCS, Milano, Italy

* To whom correspondence should be addressed.
Emanuela Taioli, E-mail: taioli{at}policlinico.mi.it


  Abstract

Leptin is an important regulator of the mass of adipose tissue and of body weight; it operates by inhibiting food intake and stimulating energy expenditure. Some polymorphic genes involved in the regulation of leptin--the leptin gene (LEP A19G), the leptin receptor gene (LEPR Q223R, K109R, and K656N), and the peroxisome proliferator-activated receptor-gamma gene (PPARG P12A and C161T)--have been investigated as possible factors associated with obesity. Allelic frequencies of these polymorphisms show ethnic variation. The authors performed a meta-analysis of the available data on the association between these polymorphisms and obesity based on case-control studies. Odds ratios and 95% confidence intervals for obesity associated with leptin polymorphisms were calculated by using both fixed- and random-effects models. Results suggest no evidence of association between the genes under study and obesity. The lack of association could be due to the complex pathogenesis of obesity, which involves a number of genetic and environmental factors. Large studies including testing of multiple genes in both obese and lean subjects, with epidemiologic data on dietary habits in different ethnic groups, are necessary to better understand the role of leptin in regulating weight in human populations.

Keywords: epidemiology; genetics; LEP; LEPR; leptin; meta-analysis; obesity; PPARG.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
V. M. Chia, P. A. Newcomb, J. W. Lampe, E. White, M. T. Mandelson, A. McTiernan, and J. D. Potter
Leptin Concentrations, Leptin Receptor Polymorphisms, and Colorectal Adenoma Risk
Cancer Epidemiol. Biomarkers Prev., December 1, 2007; 16(12): 2697 - 2703.
[Abstract] [Full Text] [PDF]

Home page
 J ANIM SCIHome page
M. Piles, M. Garcia-Tomas, O. Rafel, J. Ramon, N. Ibanez-Escriche, and L. Varona
Individual efficiency for the use of feed resources in rabbits
J Anim Sci, November 1, 2007; 85(11): 2846 - 2853.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
E. A Ruiz-Narvaez, P. Kraft, and H. Campos
Ala12 variant of the peroxisome proliferator-activated receptor-{gamma} gene (PPARG) is associated with higher polyunsaturated fat in adipose tissue and attenuates the protective effect of polyunsaturated fat intake on the risk of myocardial infarction
Am. J. Clinical Nutrition, October 1, 2007; 86(4): 1238 - 1242.
[Abstract] [Full Text] [PDF]

Home page
 Epidemiol RevHome page
W. Yang, T. Kelly, and J. He
Genetic Epidemiology of Obesity
Epidemiol. Rev., June 12, 2007; (2007) mxm004v1.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
M. Hoenig, K. Thomaseth, M. Waldron, and D. C. Ferguson
Insulin sensitivity, fat distribution, and adipocytokine response to different diets in lean and obese cats before and after weight loss
Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2007; 292(1): R227 - R234.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.