American Journal of Epidemiology Vol. 91, No. 6: 547-552
Copyright © 1970 by The Johns Hopkins University School of Hygiene and Public Health
research-article |
ANTIBODIES TO HERPESVIRUS HOMINIS TYPES 1 AND 2 IN HUMANS
II. WOMEN WITH CERVICAL CANCER1
Reprint requests to Dr: A. Nahmias, Department of Pediatrics, Emory University School of Medicine, 69 Butler Street, S. E., Atlanta, Georgia 30303.
Nahmias, A. J., W. E. Josey, Z. M. Naib, C F. Luce and B. A. Guest (Emory Univ. School of Medicine, Atlanta, Ga. 30303). Antibodies to Herpesvirvs hominis types 1 and 2 in humans. II. Women with cervical cancer. Amer. J. Epid., 1970, 97: 547–552.—The microneutralization test permitting differentiation of Herpesvirvs hominis (HVH) type antibodies was used to study sera obtained from 167 women with invasive and preinvaslve ana plastic lesions of the cervix. Similar serologic studies were done on an equal number of women matched for socioeconomic status, race and age. The percentage of women having type 2 and dual antibodies in the study and control groups was found to be as follows: (a) invasive carcinoma, 83%, controls, 35%; (b) in-situ cervical carcinoma, 70%, controls, 24%; (c) histotogically confirmed cervical dysplasia, 56%, controls, 18%; (d) cervical atypia diagnosed by cytological examination only, 40%, controls, 20%. There thus appeared to be a gradation in the percentages of women with type 2 antibodies from cytologically diagnosed atypia to invasive cervical carcinoma. The findings presented here, as well as those reported elsewhere, demonstrate a definite association between genital herpes and cervkal anaplasia. Further investigation is needed to substantiate a causal relationship.
antibodies; cancer, cervical; carcinoma; cervix neoplasms; Herpesvirvs hominis; types 1 and 2
2Research Career Development Awardee 5-K3-AI-18, 687 from the National Institutes of Allergy and Infectious Diseases
1From the Departments of Pediatrics, Preventive Medicine, Gynecology and Obstetrics, and Pathology, Emory University School of Medicine and Grady Memorial Hospital, Atlanta, Georgia. Presented in part at the First International Congress for Virology, Helsinki, June, 1968. This study was supported by research grants from the American Cancer Society (10194), National Institutes of Health (AI 08330), and the Winship Clinic, Emory University.
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