American Journal of Epidemiology Vol. 91, No. 6: 539-546
Copyright © 1970 by The Johns Hopkins University School of Hygiene and Public Health
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ANTIBODIES TO HERPESVIRUS HOMINIS TYPES 1 AND 2 IN HUMANS1
I. PATIENTS WITH GENITAL HEHPETIC INFECTIONS
Nahmias, A. J., W. E. Josey, Z. M. Naib, C F. Luce and A. DuflFey (Emory Univ. School of Medicine, Atlanta/ Ga. 30303). Antibodies to Hwpesvirus hominis types 1 and 2 in humans. I. Patients with genital herpetic infections. Amer. J. Epid., 1970, 97: 539–546.—Use of a microneutralization test and quanta I method of analysis permits the differentiation of Herpesvirus hominis (HVH) antibodies into type 1, intermediate or type 2 antibodies. A study of sera obtained from 239 individuals of varying ages in a lower socioeconomk: population showed that, beyond the new-bom age group, type 2 or intermediate antibodies were found only in sera of individuals beyond the age of 14 years. In a second study of 122 patients with genital HVH type 2 infections, one-third were found to be primary cases; one-fourth had type 1 antibodies, another fourth had intermediate antibodies, and 16% had type 2 antibodies in their acute serum. These results demonstrate that type 2 HVH infections can occur in individuals with prior type 1 infections and provide further evidence that intermediate antibodies are dual antibodies, representing prior exposure to both HVH type 1 and 2 infection.
antibodies; Herpesvirus hominis, types 1 and 2; herpesvirus infections, genital
1From the Departments of Pediatrics, Preventive Medicine, Gynecology and Obstetrics, and Pathology, Emory University School of Medicine and Grady Memorial Hospital, Atlanta, Georgia. Presented in part at the First International Congress for Virology, Helsinki, June 1968. This study was supported by research grants from the National Institutes of Health (AI 08330), and a contract DADA 17-68-C-8141 from the Office of the Surgeon General.
2Research Career Development Awardee 5-K3-AI-18, 687 from the National Institutes of Allergy and Infectious Diseases. Reprint requests to Dr. A. Nahmias, Department of Pediatrics, Emory University School of Medicine, 69 Butler Street, S. E., Atlanta, Georgia 30303
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