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American Journal of Epidemiology Advance Access originally published online on October 3, 2008
American Journal of Epidemiology 2008 168(11):1259-1267; doi:10.1093/aje/kwn248
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American Journal of Epidemiology © The Author 2008. Published by the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org.

ORIGINAL CONTRIBUTIONS

Maternal Body Mass Index and Lifestyle Exposures and the Risk of Bilateral Renal Agenesis or Hypoplasia

The National Birth Defects Prevention Study

Jennifer E. Slickers, Andrew F. Olshan, Anna Maria Siega-Riz, Margaret A. Honein, Arthur S. Aylsworth and for the National Birth Defects Prevention Study

Correspondence to Dr. Andrew F. Olshan, Department of Epidemiology, Campus Box 7435, School of Public Health, University of North Carolina, Chapel Hill, NC 27599-7435 (e-mail: andy_olshan{at}unc.edu).

Received for publication March 3, 2008. Accepted for publication July 16, 2008.

Increased maternal body mass index, maternal smoking, and alcohol exposure during pregnancy have been inconsistently reported as potential risk factors for renal birth defects. The low incidence of the most severe renal anomaly, bilateral renal agenesis or hypoplasia (RA/H), has limited the ability to study this fatal defect. Using data from the National Birth Defects Prevention Study, a multicenter case-control study, the authors explored potential relations between RA/H and maternal body mass index, smoking, alcohol, and caffeine exposures. Data available for 75 infants with RA/H born between 1997 and 2003 and for randomly selected control infants without known birth defects (n = 868) were assessed by a model adjusted for folic acid use, all four exposures of interest, and study center. Bilateral RA/H was associated with a body mass index of greater than 30 kg/m2 prior to pregnancy (adjusted odds ratio (aOR) = 1.92, 95% confidence interval (CI): 1.00, 3.67), smoking during the periconceptional period (aOR = 2.09, 95% CI: 1.08, 4.03), and binge drinking during the second month of pregnancy (aOR = 3.64, 95% CI: 1.19, 11.1). These results support the need for further exploration into the potential mechanisms by which such exposures could interfere with early fetal kidney formation resulting in RA/H.

alcohol drinking; body mass index; caffeine; case-control studies; congenital abnormalities; kidney; pregnancy; smoking

Abbreviations: aOR, adjusted odds ratio; CI, confidence interval; OR, odds ratio; RA/H, bilateral renal agenesis or hypoplasia


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