Skip Navigation


American Journal of Epidemiology Advance Access originally published online on February 12, 2008
American Journal of Epidemiology 2008 167(5):586-597; doi:10.1093/aje/kwm361
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
167/5/586    most recent
kwm361v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Stolzenberg-Solomon, R. Z.
Right arrow Articles by Silverman, D. T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Stolzenberg-Solomon, R. Z.
Right arrow Articles by Silverman, D. T.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

American Journal of Epidemiology Published by the Johns Hopkins Bloomberg School of Public Health 2008.

ORIGINAL CONTRIBUTIONS

Adiposity, Physical Activity, and Pancreatic Cancer in the National Institutes of Health–AARP Diet and Health Cohort

Rachael Z. Stolzenberg-Solomon1, Kenneth Adams1, Michael Leitzmann1, Catherine Schairer2, Dominique S. Michaud3, Albert Hollenbeck4, Arthur Schatzkin1 and Debra T. Silverman5

1 Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD
2 Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD
3 Department of Epidemiology, Harvard School of Public Health, Boston, MA
4 Environmental Analysis Department, AARP, Washington, DC
5 Occupational Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD

Correspondence to Dr. Rachael Stolzenberg-Solomon, 6120 Executive Boulevard, Suite 320, Rockville, MD 20852 (e-mail: rs221z{at}nih.gov).

Received for publication March 23, 2007. Accepted for publication November 5, 2007.

Obesity and lack of physical activity have been inconsistently associated with pancreatic cancer. Using data from a self-administered baseline questionnaire (1995–1996), the authors investigated the association between adiposity and physical activity and pancreatic cancer in 495,035 participants of the National Institutes of Health–AARP Diet and Health Study who were aged 50–71 years. To avoid the influence of subclinical disease, follow-up time started 1 year after baseline, and subjects with a body mass index (BMI) of <18.5 kg/m2 were excluded. A subcohort (n = 302,060) completed a second questionnaire with information about physical activity and waist and hip circumference. During follow-up though 2000, 654 pancreatic cancer cases were identified. The authors used Cox proportional hazard models to generate adjusted hazard ratios and 95% confidence intervals. Compared with those with a BMI of 18.5–<25, those with a BMI of ≥35 had a 45% greater pancreatic cancer risk (95% confidence interval (CI): 1.04, 2.02; ptrend = 0.02). Significant positive associations for BMI were observed among nonsmokers (for BMI ≥35: hazard ratio = 1.70, 95% CI: 1.14, 2.53; ptrend = 0.004) but not recent smokers (pinteraction = 0.08). Waist circumference was positively associated with pancreatic cancer (fourth vs. first quartile: hazard ratio = 2.53, 95% CI: 1.13, 5.65; ptrend = 0.04) in women but not men. The authors observed no association with physical activity. Their results suggest a positive association between adiposity and pancreatic cancer.

adenocarcinoma; adiposity; body mass index; cohort studies; exercise; pancreatic neoplasms; smoking; waist-hip ratio

Abbreviations: BMI, body mass index; CI, confidence interval; HR, hazard ratio; MET, metabolic equivalent; NIH, National Institutes of Health


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Integr Cancer TherHome page
S. Kranz
Integrative Tumor Board: Pancreatic Cancer Physical Therapy
Integr Cancer Ther, June 1, 2008; 7(2): 108 - 110.
[PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.