Skip Navigation


American Journal of Epidemiology Advance Access originally published online on July 23, 2007
American Journal of Epidemiology 2007 166(8):941-950; doi:10.1093/aje/kwm203
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
166/8/941    most recent
kwm203v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (5)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Wigertz, A.
Right arrow Articles by Feychting, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wigertz, A.
Right arrow Articles by Feychting, M.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

American Journal of Epidemiology © The Author 2007. Published by the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org.

ORIGINAL CONTRIBUTIONS

Allergic Conditions and Brain Tumor Risk

Annette Wigertz1, Stefan Lönn1, Judith Schwartzbaum1,2, Per Hall3, Anssi Auvinen4,5, Helle Collatz Christensen6, Christoffer Johansen6, Lars Klæboe7, Tiina Salminen5, Minouk J. Schoemaker8, Anthony J. Swerdlow8, Tore Tynes7,9 and Maria Feychting1

1 Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
2 Division of Epidemiology and Biometrics, School of Public Health, Ohio State University, Columbus, OH
3 Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
4 STUK-Radiation and Nuclear Safety Authority, Helsinki, Finland
5 Tampere School of Public Health, University of Tampere, Tampere, Finland
6 Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark
7 The Cancer Registry of Norway, Institute of Population-based Cancer Research, Oslo, Norway
8 Section of Epidemiology, Institute of Cancer Research, Sutton, United Kingdom
9 National Institute of Occupational Health, Oslo, Norway

Correspondence to Dr. Annette Wigertz, Institute of Environmental Medicine, Karolinska Institutet, Box 210, S-171 77 Stockholm, Sweden (e-mail: annette.wigertz{at}ki.se).

Received for publication December 22, 2006. Accepted for publication May 8, 2007.

An inverse association between allergic conditions and glioma risk has been reported previously. In this large population-based case-control study, the authors identified cases diagnosed with glioma or meningioma in Denmark, Norway, Finland, Sweden, and southeast England between 2000 and 2004. Detailed information on self-reported physician-diagnosed allergic conditions was collected from 1,527 glioma cases, 1,210 meningioma cases, and 3,309 randomly selected controls. Logistic regression showed an odds ratio of 0.70 (95% confidence interval: 0.61, 0.80) for glioma associated with a diagnosis of any of asthma, hay fever, eczema, or other type of allergy. The risk estimates for glioma were around 0.65 for each allergic condition (asthma, eczema, hay fever, and food allergy), and the 95% confidence intervals were equally consistent, at around 0.55, 0.80. The reduced risks of glioma related to eczema, hay fever, and allergy overall, but not asthma, were confined to current rather than past conditions. Meningioma risk was not associated with allergic conditions, except for eczema (odds ratio = 0.74, 95% confidence interval: 0.60, 0.91). Our results show a reduced risk for glioma associated primarily with current allergic conditions. If this is etiologic, it has implications for the understanding of how allergic conditions might reduce the tumor risk.

asthma; case-control studies; eczema; glioma; hypersensitivity; meningioma; rhinitis, allergic, seasonal

Abbreviations: CI, confidence interval; ICD-10, International Classification of Diseases, Tenth Revision; ICD-O-2, International Classification of Diseases for Oncology, Second Edition; IgE, immunoglobulin IgE; UICC, International Union against Cancer


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
M. E. Scheurer, R. El-Zein, P. A. Thompson, K. D. Aldape, V. A. Levin, M. R. Gilbert, J. S. Weinberg, and M. L. Bondy
Long-term Anti-inflammatory and Antihistamine Medication Use and Adult Glioma Risk
Cancer Epidemiol. Biomarkers Prev., May 1, 2008; 17(5): 1277 - 1281.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
A.V. Brenner, M.A. Butler, S.S. Wang, A.M. Ruder, N. Rothman, P.A. Schulte, S.J. Chanock, H.A. Fine, M.S. Linet, and P.D. Inskip
Single-nucleotide polymorphisms in selected cytokine genes and risk of adult glioma
Carcinogenesis, December 1, 2007; 28(12): 2543 - 2547.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
J. A. Schwartzbaum, A. Ahlbom, S. Lonn, B. Malmer, A. Wigertz, A. Auvinen, A. J. Brookes, H. Collatz Christensen, R. Henriksson, C. Johansen, et al.
An International Case-Control Study of Interleukin-4R{alpha}, Interleukin-13, and Cyclooxygenase-2 Polymorphisms and Glioblastoma Risk
Cancer Epidemiol. Biomarkers Prev., November 1, 2007; 16(11): 2448 - 2454.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.