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American Journal of Epidemiology Advance Access originally published online on July 5, 2007
American Journal of Epidemiology 2007 166(5):544-551; doi:10.1093/aje/kwm120
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American Journal of Epidemiology © The Author 2007. Published by the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org.

ORIGINAL CONTRIBUTIONS

Plasma Fluorescent Oxidation Products: Independent Predictors of Coronary Heart Disease in Men

Tianying Wu1, Nader Rifai2, Walter C. Willett1,3,4 and Eric B. Rimm1,3,4

1 Department of Nutrition, Harvard School of Public Health, Boston, MA
2 Department of Laboratory Medicine, Children's Hospital and Harvard Medical School, Boston, MA
3 Department of Epidemiology, Harvard School of Public Health, Boston, MA
4 Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women's Hospital, Boston, MA

Correspondence to Dr. Tianying Wu, Department of Nutrition, Harvard School of Public Health, 655 Huntington Avenue, Boston, MA 02115 (e-mail: hptwu{at}channing.harvard.edu; tianying.wu{at}uc.edu).

Received for publication June 20, 2006. Accepted for publication October 20, 2006.

Fluorescent oxidation products in plasma are stable with routine blood collection methods and reflect oxidation in food, animals, and in vitro. Whether plasma fluorescent oxidation products predict future coronary heart disease has not been established. Among US men without cardiovascular disease who provided blood specimens in 1994 in the Health Professionals Follow-up Study, the authors confirmed 266 incident nonfatal myocardial infarction or fatal coronary heart disease endpoints during 6 years of follow-up. Using a nested case-control design, they measured baseline levels of fluorescent oxidation products. Each case was matched with two controls according to age, smoking status, and time of blood draw. The relative risk of coronary heart disease between extreme quintiles was 1.83 (95% confidence interval: 1.07, 3.13; p for trend = 0.005) in the multivariate analysis controlling for other cardiovascular risk factors and traditional lipid markers. Further adjustment for C-reactive protein and glycated hemoglobin A1c did not materially attenuate this association. The multivariate-adjusted relative risk between extreme quintiles was 3.36 (95% confidence interval: 1.33, 8.48; p for trend = 0.005) when the analysis was restricted to men who had fasted for more than 10 hours before blood draw. The authors found that plasma fluorescent oxidation products significantly and independently predicted coronary heart disease incidence among men without previous cardiovascular events.

biological markers; coronary disease; fluorescence; myocardial infarction; oxidation-reduction; oxidative stress; plasma; risk factors

Abbreviations: AIC, Akaike's Information Criterion; CHD, coronary heart disease; CI, confidence interval; CRP, C-reactive protein


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