Skip Navigation


American Journal of Epidemiology Advance Access originally published online on July 5, 2007
American Journal of Epidemiology 2007 166(5):544-551; doi:10.1093/aje/kwm120
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
166/5/544    most recent
kwm120v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (1)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Wu, T.
Right arrow Articles by Rimm, E. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wu, T.
Right arrow Articles by Rimm, E. B.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

American Journal of Epidemiology © The Author 2007. Published by the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org.

ORIGINAL CONTRIBUTIONS

Plasma Fluorescent Oxidation Products: Independent Predictors of Coronary Heart Disease in Men

Tianying Wu1, Nader Rifai2, Walter C. Willett1,3,4 and Eric B. Rimm1,3,4

1 Department of Nutrition, Harvard School of Public Health, Boston, MA
2 Department of Laboratory Medicine, Children's Hospital and Harvard Medical School, Boston, MA
3 Department of Epidemiology, Harvard School of Public Health, Boston, MA
4 Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women's Hospital, Boston, MA

Correspondence to Dr. Tianying Wu, Department of Nutrition, Harvard School of Public Health, 655 Huntington Avenue, Boston, MA 02115 (e-mail: hptwu{at}channing.harvard.edu; tianying.wu{at}uc.edu).

Received for publication June 20, 2006. Accepted for publication October 20, 2006.

Fluorescent oxidation products in plasma are stable with routine blood collection methods and reflect oxidation in food, animals, and in vitro. Whether plasma fluorescent oxidation products predict future coronary heart disease has not been established. Among US men without cardiovascular disease who provided blood specimens in 1994 in the Health Professionals Follow-up Study, the authors confirmed 266 incident nonfatal myocardial infarction or fatal coronary heart disease endpoints during 6 years of follow-up. Using a nested case-control design, they measured baseline levels of fluorescent oxidation products. Each case was matched with two controls according to age, smoking status, and time of blood draw. The relative risk of coronary heart disease between extreme quintiles was 1.83 (95% confidence interval: 1.07, 3.13; p for trend = 0.005) in the multivariate analysis controlling for other cardiovascular risk factors and traditional lipid markers. Further adjustment for C-reactive protein and glycated hemoglobin A1c did not materially attenuate this association. The multivariate-adjusted relative risk between extreme quintiles was 3.36 (95% confidence interval: 1.33, 8.48; p for trend = 0.005) when the analysis was restricted to men who had fasted for more than 10 hours before blood draw. The authors found that plasma fluorescent oxidation products significantly and independently predicted coronary heart disease incidence among men without previous cardiovascular events.

biological markers; coronary disease; fluorescence; myocardial infarction; oxidation-reduction; oxidative stress; plasma; risk factors

Abbreviations: AIC, Akaike's Information Criterion; CHD, coronary heart disease; CI, confidence interval; CRP, C-reactive protein


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Am J EpidemiolHome page
R. Meerwaldt, T. Links, C. Zeebregts, and A. Smit
RE: "PLASMA FLUORESCENT OXIDATION PRODUCTS AS POTENTIAL MARKERS OF OXIDATIVE STRESS FOR EPIDEMIOLOGIC STUDIES"
Am. J. Epidemiol., March 15, 2008; 167(6): 756 - 757.
[Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.