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American Journal of Epidemiology Advance Access originally published online on October 31, 2007
American Journal of Epidemiology 2007 166(12):1479-1480; doi:10.1093/aje/kwm303
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American Journal of Epidemiology © The Author 2007. Published by the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org.

LETTERS TO THE EDITOR

RE: "INVITED COMMENTARY: HORMONE THERAPY AND RISK OF CORONARY HEART DISEASE—WHY RENEW THE FOCUS ON THE EARLY YEARS OF MENOPAUSE?"

Martina Dören1 and Eberhard M. Greiser2

1 Clinical Research Center of Women's Health, Charité-Universitätsmedizin Berlin, D-12200 Berlin, Germany
2 Institute for Public Health and Nursing Research, Faculty of Health Sciences, Bremen University, D-28259 Bremen, Germany

(e-mail: martina.doeren@charite.de)

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The meta-analysis by Salpeter et al. (1) is ineligible to support the validity of the "timing hypothesis" discussed by Manson and Bassuk in a recent Journal article (2), because this work suffers from methodological shortcomings. The objective to disentangle associations between coronary heart disease and use of menopausal hormone therapies was obscured by including not only trials with defined coronary heart disease events, monitored . . . [Full Text of this Article]


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