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American Journal of Epidemiology Advance Access originally published online on September 17, 2007
American Journal of Epidemiology 2007 166(10):1138-1139; doi:10.1093/aje/kwm253
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American Journal of Epidemiology © The Author 2007. Published by the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org.

Response to Invited Commentary

Pesonen et al. Respond to "The Life Course Epidemiology of Depression"

A-K. Pesonen1, K. Räikkönen1, K. Heinonen1, E. Kajantie2, T. Forsén2 and J. G. Eriksson3

1 Department of Psychology, University of Helsinki, Helsinki, Finland
2 National Public Health Institute, Helsinki, Finland
3 Department of Public Health, University of Helsinki, Helsinki, Finland

Correspondence to Dr. Katri Räikkönen, Department of Psychology, University of Helsinki, P.O. Box 9, Siltavuorenpenger 20 R, Helsinki FI-00014, Finland (e-mail: katri.raikkonen@helsinki.fi).

Received for publication July 10, 2007. Accepted for publication August 13, 2007.

The first 10% of the full text of this article appears below.

In his insightful commentary on our recent publication (1), Gilman (2) mentions three potential challenges with implications for life-course research.

First, confounders related to unobserved factors are of major importance in all scientific research. Exceptional conditions, such as in Finland during World War II, are comparable to major environmental disasters. They are particularly significant to natural experimental designs because potential confounders are assumed to be randomly distributed across the groups . . . [Full Text of this Article]


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Related articles in Am. J. Epidemiol.:

Depressive Symptoms in Adults Separated from Their Parents as Children: A Natural Experiment during World War II
Anu-Katriina Pesonen, Katri Räikkönen, Kati Heinonen, Eero Kajantie, Tom Forsén, and Johan G. Eriksson
Am. J. Epidemiol. 2007 166: 1126-1133. [Abstract] [FREE Full Text]