American Journal of Epidemiology Advance Access originally published online on October 13, 2006
American Journal of Epidemiology 2007 165(1):44-52; doi:10.1093/aje/kwj353
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ORIGINAL CONTRIBUTIONS |
Height and Body Mass Index and Risk of Lymphohematopoietic Malignancies in Two Million Norwegian Men and Women
1 Division of Epidemiology, Norwegian Institute of Public Health, Oslo, Norway
2 Section for Epidemiology and Medical Statistics, Department of Public Health and Primary Health Care, University of Bergen, Bergen, Norway
3 The Cancer Registry of Norway, Institute of Population-based Cancer Research, Oslo, Norway
Correspondence to Dr. Anders Engeland, Division of Epidemiology, Norwegian Institute of Public Health, P.O. Box 4404 Nydalen, N-0403 Oslo, Norway (e-mail: anders.engeland{at}isf.uib.no).
Reports on the association between obesity and lymphohematopoietic malignancies (LHMs) have been inconsistent. The present study aimed at exploring this association for specific disease lymphohematopoietic entities in a large Norwegian cohort. Height and weight were measured in two million Norwegian men and women aged 20–74 years during 1963–2001. During follow-up, 24,500 cases of LHMs were observed. Relative risks of disease were estimated by Cox proportional hazards regression. The risk of LHMs overall increased moderately by increasing body mass index and height in both sexes. The relative risk of LHMs per five-unit increase in body mass index was 1.11 (95% confidence interval (CI): 1.08, 1.14) in men and 1.08 (95% CI: 1.05, 1.11) in women. For each 10-cm increase in height, the relative risk was 1.19 (95% CI: 1.16, 1.22) in men and 1.16 (95% CI: 1.12, 1.20) in women. Separate analyses for different lymphohematopoietic malignancies did not reveal any group's being particularly strongly associated with body mass index. A modest increase in the risk of LHMs combined was observed with increasing height. The moderate associations between height and body mass index and LHMs found in the present study indicate that the observed increase in overweight/obesity plays only a minor role in explaining the increase in the incidence of LHMs.
body height; body mass index; hematologic neoplasms; leukemia; lymphoma; multiple myeloma; Norway; risk
Abbreviations: CI, confidence interval; LHM, lymphohematopoietic malignancy
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