American Journal of Epidemiology Advance Access originally published online on July 13, 2006
American Journal of Epidemiology 2006 164(5):497-504; doi:10.1093/aje/kwj223
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Original Contribution |
Use of Nonsteroidal Antiinflammatory Drugs and Non-Hodgkin Lymphoma: A Population-based Case-Control Study
1 Department of Epidemiology, Harvard School of Public Health, Boston, MA
2 Department of Epidemiology and Biostatistics, University of California School of Medicine, San Francisco, CA
3 Department of Health Research and Policy, Stanford University School of Medicine, Stanford, CA
Correspondence to Dr. Elizabeth A. Holly, Department of Epidemiology and Biostatistics, University of California School of Medicine, Box 1228, 500 Parnassus Avenue, San Francisco, CA 94143-1228 (e-mail: elizabeth.holly{at}ucsf.edu).
The association between long-term use of nonsteroidal antiinflammatory drugs (NSAIDs) and non-Hodgkin lymphoma (NHL) was examined using data collected between October 2001 and May 2004 in an ongoing population-based case-control study in the San Francisco Bay Area. NHL cases were identified using rapid case ascertainment and Surveillance, Epidemiology, and End Results registry data. Control participants were frequency-matched to cases by age, sex, and county of residence. Participants completed in-person interviews designed to measure potential NHL risk factors. Questions were asked regarding use during the past 20 years of aspirin, prescription and over-the-counter nonselective NSAIDs, and cyclooxygenase-2 (COX-2) inhibitors. A total of 1,000 cases and 1,060 controls contributed data for these interim analyses. Analyses were carried out for men and women and for both sexes combined. After adjustment for age and sex, there was no consistent association between long-term use and NHL for all NSAIDs combined, aspirin, nonselective NSAIDs, and COX-2 inhibitors. For women, long-term aspirin use may be associated with a decreased risk of NHL (for 3–<9 years of use, odds ratio = 0.41, 95% confidence interval: 0.18, 0.94). Conversely, although the confidence intervals were wide, the adjusted odds ratios for COX-2 inhibitor use were nearly twofold for women, indicating a possible increase in NHL risk associated with regular use of COX-2 inhibitors.
anti-inflammatory agents, non-steroidal; aspirin; case-control studies; cyclooxygenase inhibitors; lymphoma, non-Hodgkin
Abbreviations: COX-2, cyclooxygenase-2; HIV, human immunodeficiency virus; NHL, non-Hodgkin lymphoma; NSAID(s), nonsteroidal antiinflammatory drug(s)
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