American Journal of Epidemiology Advance Access originally published online on August 10, 2005
American Journal of Epidemiology 2005 162(6):579-584; doi:10.1093/aje/kwi237
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
ORIGINAL CONTRIBUTIONS |
Helicobacter pylori and Overweight Status in the United States: Data from the Third National Health and Nutrition Examination Survey
1 Department of Medicine, New York University School of Medicine, New York, NY
2 VA New York Harbor Healthcare System, New York, NY
3 Division of Biostatistics, Department of Environmental Medicine, New York University School of Medicine, New York, NY
Correspondence to Dr. Edmund J. Bini, Division of Gastroenterology, VA New York Harbor Healthcare System, 423 East 23rd Street, New York, NY 10010 (e-mail: Edmund.Bini{at}med.va.gov).
Obesity is an important public health problem in the United States. Because of its potential effects on gastric leptin homeostasis, Helicobacter pylori may play a role in regulating body weight. The authors' aim in this study was to examine the association between H. pylori colonization and overweight status. Nonpregnant participants in the Third National Health and Nutrition Examination Survey (1988–1994) aged 
20 years who had had H. pylori testing performed and body mass index (weight (kg)/height (m)2) measured were studied. Overweight was defined as a body mass index greater than or equal to 25. On the basis of serologic results, the participants were categorized into three H. pylori status groups: H. pylori-positive and cytotoxin-associated gene A (cagA)-positive (H. pylori+cagA+), H. pylori-positive and cagA-negative (H. pylori+cagA–), and H. pylori-negative (H. pylori–). Of the 7,003 subjects with complete body mass index and H. pylori data, 2,634 (weighted percentage, 22.9%) were H. pylori+cagA+, 1,385 (15.1%) were H. pylori+cagA–, and 2,984 (62.0%) were H. pylori–. The adjusted odds of being overweight were 1.17 (95% confidence interval: 0.98, 1.39; p = 0.075) for the H. pylori+cagA+ group and 0.99 (95% confidence interval: 0.80, 1.22; p = 0.92) for the H. pylori+cagA– group in comparison with H. pylori– subjects. Serum leptin levels did not differ significantly between the three H. pylori groups. In this US population-based study, there was no significant association between H. pylori colonization, cagA+ strains of H. pylori, and being overweight.
body mass index; body weight; cagA protein, Helicobacter pylori; Helicobacter pylori; obesity
Abbreviations: cagA, cytotoxin-associated gene A; NHANES III, Third National Health and Nutrition Examination Survey
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  S. Talarico, B. D. Gold, J. Fero, D. T. Thompson, J. Guarner, S. Czinn, and N. R. Salama Pediatric Helicobacter pylori Isolates Display Distinct Gene Coding Capacities and Virulence Gene Marker Profiles J. Clin. Microbiol., June 1, 2009; 47(6): 1680 - 1688. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Roper, F. Francois, P. L. Shue, M. S. Mourad, Z. Pei, A. Z. Olivares de Perez, G. I. Perez-Perez, C.-H. Tseng, and M. J. Blaser Leptin and Ghrelin in Relation to Helicobacter pylori Status in Adult Males J. Clin. Endocrinol. Metab., June 1, 2008; 93(6): 2350 - 2357. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Chen and M. J. Blaser Inverse Associations of Helicobacter pylori With Asthma and Allergy Arch Intern Med, April 23, 2007; 167(8): 821 - 827. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. MARINI, A. L. MALDONADO-CONTRERAS, S. CABRAS, G. HIDALGO, R. BUFFA, A. MARIN, G. FLORIS, W. RACUGNO, L. R. PERICCHI, M. E. CASTELLANOS, et al. HELICOBACTER PYLORI AND INTESTINAL PARASITES ARE NOT DETRIMENTAL TO THE NUTRITIONAL STATUS OF AMERINDIANS Am J Trop Med Hyg, March 1, 2007; 76(3): 534 - 540. [Abstract] [Full Text] [PDF]
|
|