American Journal of Epidemiology Advance Access originally published online on July 13, 2005
American Journal of Epidemiology 2005 162(4):351-357; doi:10.1093/aje/kwi207
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ORIGINAL CONTRIBUTIONS |
Helicobacter pylori Infection in Different Generations of Hispanics in the San Francisco Bay Area
1 Department of Health Research and Policy, Stanford University School of Medicine, Stanford, CA
2 Department of Medicine, Stanford University School of Medicine, Stanford, CA
Reprint requests to Dr. Julie Parsonnet, Departments of Medicine and Health Research and Policy, Stanford University School of Medicine, Grant Building, Room S156, 300 Pasteur Drive, Stanford, CA 94305-5107 (e-mail: parsonnt{at}stanford.edu).
To quantify the contributions of household and environmental factors to Helicobacter pylori infection, the authors examined H. pylori infection among several generations of Hispanics in the San Francisco Bay Area. Between 2000 and 2004, household members were tested for H. pylori and interviewed about demographic factors and household pedigree. An immigrant was defined as someone born in Latin America with at least one Latin America-born parent; a first-generation US-born Hispanic was defined as someone born in the United States with at least one Latin America-born parent; and a second-generation US-born Hispanic was defined as someone born in the United States with at least one US-born parent. Prevalences of H. pylori in immigrants and first- and second-generation US-born Hispanics were 31.4% (102/325), 9.1% (98/1,076), and 3.1% (2/64), respectively. Compared with second-generation US-born Hispanics, the age-adjusted odds ratios for H. pylori were 9.70 (95% confidence interval (CI): 1.57, 60.00) for immigrants and 4.32 (95% CI: 0.69, 26.96) for first-generation US-born Hispanics (ptrend < 0.001). These odds ratios decreased to 6.19 (95% CI: 1.13, 33.77) and 3.24 (95% CI: 0.59, 17.82), respectively, after adjustment for parental infection (odds ratio (OR) = 2.94, 95% CI: 1.59, 4.38), low education (OR = 1.76, 95% CI: 1.20, 2.68), and crowding (OR = 1.23, 95% CI: 0.84, 1.79). Both the household and birth-country environments probably contributed to declining H. pylori prevalence among successive generations of Hispanics.
disease transmission; Helicobacter pylori; Hispanic Americans; immigrants; infection; prevalence; social class
Abbreviations: CI, confidence interval; SIFT, Stanford Infection and Familial Transmission
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