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American Journal of Epidemiology 2005 161(12):1102-1106; doi:10.1093/aje/kwi148
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American Journal of Epidemiology Copyright © 2005 by the Johns Hopkins Bloomberg School of Public Health All rights reserved

ORIGINAL CONTRIBUTIONS

Invited Commentary: Acne in Adolescence—Protecting the Heart but Damaging the Prostate Later in Life?

Earl S. Ford1 and Simin Liu2,3

1 Division of Adult and Community Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA
2 Division of Preventive Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA
3 Department of Epidemiology, Harvard School of Public Health, Boston, MA

Correspondence to Dr. Earl Ford, Centers for Disease Control and Prevention, 4770 Buford Highway, MS K66, Atlanta, GA 30341 (e-mail: eford@cdc.gov).

Received for publication February 24, 2005. Accepted for publication March 7, 2005.

Abbreviations: SHBG, sex hormone-binding globulin

The first 150 words of the full text of this article appear below.

Man is only man at the surface. Remove the skin, dissect, and immediately you come to machinery.

   —Paul Valery, French critic and poet (1871–1945)

Cutaneous manifestations of diseases have long helped observant clinicians to establish a diagnosis (1Go), but can cutaneous clues or other physical characteristics predict the risk of mortality or incident disease far into the future? For some time, researchers have linked with mixed success various physical manifestations to the risk of developing diseases, such as coronary heart disease. Among these physical markers are earlobe crease (2Go), arcus senilis (3Go), baldness (4Go), early hair graying (5Go), and facial wrinkling (6Go). Good reasons exist for studying the associations between physical markers and disease endpoints, because physical characteristics may help not only to elucidate underlying pathogenetic processes for diseases but also to detect persons at increased risk who would benefit by early intervention.

. . . [Full Text of this Article]


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