Am J Epidemiol 2003; 158:1182-1192.
Copyright © 2003 by the Johns
Hopkins Bloomberg School of Public Health
ORIGINAL CONTRIBUTIONS |
Cancer Risk among Workers at Danish Companies using Trichloroethylene: A Cohort Study
1 Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark.
2 International Epidemiology Institute, Rockville, MD.
3 Department of Medicine, Vanderbilt University Medical School, Vanderbilt-Ingram Cancer Center, Nashville, TN.
4 Department of Occupational Medicine, Aarhus University Hospital, Aarhus, Denmark.
5 National Institute for Occupational Health, Copenhagen, Denmark.
Trichloroethylene is an animal carcinogen with limited evidence of carcinogenicity in humans. Cancer incidence between 1968 and 1997 was evaluated in a cohort of 40,049 blue-collar workers in 347 Danish companies with documented trichloroethylene use. Standardized incidence ratios for total cancer were 1.1 (95% confidence interval (CI): 1.04, 1.12) in men and 1.2 (95% CI: 1.14, 1.33) in women. For non-Hodgkin’s lymphoma and renal cell carcinoma, the overall standardized incidence ratios were 1.2 (95% CI: 1.0, 1.5) and 1.2 (95% CI: 0.9, 1.5), respectively; standardized incidence ratios increased with duration of employment, and elevated standardized incidence ratios were limited to workers first employed before 1980 for non-Hodgkin’s lymphoma and before 1970 for renal cell carcinoma. The standardized incidence ratio for esophageal adenocarcinoma was 1.8 (95% CI: 1.2, 2.7); the standardized incidence ratio was higher in companies with the highest probability of trichloroethylene exposure. In a subcohort of 14,360 presumably highly exposed workers, the standardized incidence ratios for non-Hodgkin’s lymphoma, renal cell carcinoma, and esophageal adenocarcinoma were 1.5 (95% CI: 1.2, 2.0), 1.4 (95% CI: 1.0, 1.8), and 1.7 (95% CI: 0.9, 2.9), respectively. The present results and those of previous studies suggest that occupational exposure to trichloroethylene at past higher levels may be associated with elevated risk for non-Hodgkin’s lymphoma. Associations between trichloroethylene exposure and other cancers are less consistent.
adenocarcinoma; biliary tract neoplasms; esophageal neoplasms; kidney neoplasms; liver neoplasms; lymphoma, non-Hodgkin; occupations; trichloroethylene
Abbreviations: Abbreviation: CI, confidence interval.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  D. D. Alexander, P. J. Mink, J. H. Mandel, and M. A. Kelsh A meta-analysis of occupational trichloroethylene exposure and multiple myeloma or leukaemia Occup. Med., October 1, 2006; 56(7): 485 - 493. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J H Mandel, M A Kelsh, P J Mink, D D Alexander, R M Kalmes, M Weingart, L Yost, and M Goodman Occupational trichloroethylene exposure and non-Hodgkin's lymphoma: a meta-analysis and review Occup. Environ. Med., September 1, 2006; 63(9): 597 - 607. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B Mester, A Nieters, E Deeg, G Elsner, N Becker, and A Seidler Occupation and malignant lymphoma: a population based case control study in Germany Occup. Environ. Med., January 1, 2006; 63(1): 17 - 26. [Abstract] [Full Text] [PDF]
|
|