Am J Epidemiol 2003; 157:774-783.
Copyright © 2003 by Johns
Hopkins Bloomberg School of Public Health
ORIGINAL CONTRIBUTIONS |
Effect of Neighborhood Social Participation on Individual Use of Hormone Replacement Therapy and Antihypertensive Medication: A Multilevel Analysis
1 Department of Community Medicine, Malmö University Hospital, Lund University, Malmö, Sweden.
2 The NEPI Foundation, Malmö University Hospital, Lund University, Malmö, Sweden.
3 Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI.
4 Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI.
5 Multilevel Models Project, Institute of Education, University of London, London, United Kingdom.
6 Danish National Institute of Public Health, Copenhagen, Denmark.
The authors investigated a possible contextual effect of neighborhood on individual use of hormone replacement therapy (HRT) and antihypertensive medication (AHM) and the impact of neighborhood social participation on individual use of these medications. They attempted to disentangle contextual from individual influences. Multilevel logistic regression modeling was used to analyze data on 15,456 women aged 45–73 years (first level) residing in 95 neighborhoods (second level) of the city of Malmö, Sweden (250,000 inhabitants) who participated in the Malmö Diet and Cancer Study (1991–1996). AHM use was studied among 7,558 participants with defined hypertension. Of the total variability in medication use in this population, only 1.7% (HRT) and 0.5% (AHM) was between neighborhoods. After adjustment for age, individual socioeconomic factors, individual low levels of social participation, and health and behavioral variables, no neighborhood effect on AHM use was found. However, women living in neighborhoods with low social participation were much less likely to use HRT (odds ratio = 0.36, 95% confidence interval: 0.21, 0.63), especially if they themselves experienced low social participation (synergy index, 1.53) or were immigrants (synergy index, 1.68). The Malmö neighborhoods were homogeneous with regard to HRT and especially AHM use. However, differences in neighborhood social participation affected HRT use independently of individual characteristics.
analysis of variance; antihypertensive agents; hormone replacement therapy; pharmacoepidemiology; social environment; social medicine
Abbreviations: Abbreviations: AHM, antihypertensive medication; ATC-97, 1997 version of the Anatomic Therapeutic Chemical classification system; CI, confidence interval; HRT, hormone replacement therapy; OR, odds ratio.
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