Am J Epidemiol 2003; 157:667-673.
Copyright © 2003 by Johns
Hopkins Bloomberg School of Public Health
The Human Genome Project Is Complete. How Do We Develop a Handle for the Pump?
1 Office of Genomics and Disease Prevention, Centers for Disease Control and Prevention, Atlanta, GA.
2 Epidemiology Group, Department of Medicine and Therapeutics, University of Aberdeen, Aberdeen, Scotland.
Received for publication February 19, 2003; accepted for publication February 27, 2003.
association; epidemiology; gene frequency; genetics; genomics; meta-analysis; review literature
Abbreviations: Abbreviations: HuGE, Human Genome Epidemiology; HuGE Net, Human Genome Epidemiology Network.
| The first 150 words of the full text of this article appear below. |
"The sequencing of the human genome offers the greatest opportunity for epidemiology since John Snow discovered the Broad Street Pump" (1, p. 637).
A half century since the publication of the structure of the DNA molecule (2), the sequence of the human genome is complete. Some expect this achievement to be translated into advances in medicine and public health relatively rapidly (3–6). Proponents of this approach tend to focus on the potential to tailor primary prevention, secondary prevention, or therapy on the basis of genetic information. It is also possible that a better understanding of genetic effects and gene-environment interactions in disease processes will allow us to develop better interventions, such as avoidance of defined exposures and chemoprevention, to apply to the general population (7). Others are more skeptical (8–13). A key element
PUBLIC HEALTH APPLICATIONS
VARIATION IN MANIFESTATION
METHODOLOGICAL ISSUES
QUANTITATIVE SYNTHESIS
REPLICATION
VOLUME AND TYPE OF EVIDENCE
CALL FOR REVIEWS
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