Am J Epidemiol 2003; 157:583-591.
Copyright © 2003 by Johns
Hopkins Bloomberg School of Public Health
ORIGINAL CONTRIBUTIONS |
Does the Interaction between Maternal Folate Intake and the Methylenetetrahydrofolate Reductase Polymorphisms Affect the Risk of Cleft Lip with or without Cleft Palate?
1 Department of Epidemiology and Biostatistics, University Medical Center Nijmegen, Nijmegen, the Netherlands.
2 Department of Obstetrics and Gynecology, University Medical Center Nijmegen, Nijmegen, the Netherlands.
3 Institute of Plastic Surgery, Erasmus University Medical Center Rotterdam, Rotterdam, the Netherlands.
4 Laboratory of Pediatrics and Neurology, University Medical Center Nijmegen, Nijmegen, the Netherlands.
5 Department of Chronic Disease Epidemiology, National Institute for Public Health and the Environment, Bilthoven, the Netherlands.
6 Department of Speech and Languages, University Hospital Groningen, Groningen, the Netherlands.
7 Department of Plastic Surgery, Medical Center Leeuwarden, Leeuwarden, the Netherlands.
8 Department of Orthodontics and Oral Biology, University Medical Center Nijmegen, Nijmegen, the Netherlands.
Periconceptional folic acid supplementation may reduce the risk of cleft lip with or without cleft palate (CL(P)). Polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene reduce availability of 5-methyltetrahydrofolate, the predominant circulating form of folate. To determine the effect of MTHFR C677T and MTHFR A1298C genotypes and haplotypes on CL(P) risk and the interaction with maternal periconceptional dietary folate and folic acid supplement intake, the authors conducted a case-control triad study in the Netherlands (1998–2000) among 179 CL(P) and 204 control families. Infant and parental MTHFR C677T and MTHFR A1298C genotypes and haplotypes were not associated with CL(P) risk in the case-control and transmission disequilibrium test analyses. Mothers carrying the MTHFR 677TT genotype and who either did not use folic acid supplements periconceptionally or had a low dietary folate intake, or both, had an increased risk of delivering a CL(P) child (odds ratio (OR) = 5.9, 95% confidence interval (CI): 1.1, 30.9; OR = 2.8, 95% CI: 0.7, 10.5; OR = 10.0, 95% CI: 1.3, 79.1, respectively). No supplement use, low dietary folate intake, and maternal MTHFR 1298CC genotype increased the risk of CL(P) offspring almost sevenfold (OR = 6.5, 95% CI: 1.4, 30.2). Thus, the detrimental effect of low periconceptional folate intake on the risk of giving birth to a CL(P) child was more pronounced in mothers with the MTHFR 677TT or MTHFR 1298CC genotype.
abnormalities; folic acid; genes; nutrition; pregnancy; vitamins
Abbreviations: Abbreviations: CI, confidence interval; CL(P), cleft lip with or without cleft palate; MTHFR, methylenetetrahydrofolate reductase; OR, odds ratio.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  C. Y Johnson and J. Little Folate intake, markers of folate status and oral clefts: is the evidence converging? Int. J. Epidemiol., October 1, 2008; 37(5): 1041 - 1058. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. H. Jongbloet Non-optimal maturation of the oocyte, maternal MTHFR polymorphisms, periconceptional folate, and decrease of congenital heart defects Eur. Heart J., August 2, 2007; 28(16): 2043 - 2043. [Full Text] [PDF]
|
|
|
|
 |
|
 T. V. Pereira, M. Rudnicki, A. C. Pereira, M. S. Pombo-de-Oliveira, and R. F. Franco 5,10-Methylenetetrahydrofolate Reductase Polymorphisms and Acute Lymphoblastic Leukemia Risk: A Meta-analysis. Cancer Epidemiol. Biomarkers Prev., October 1, 2006; 15(10): 1956 - 1963. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Tamura and M. F. Picciano Folate and human reproduction Am. J. Clinical Nutrition, May 1, 2006; 83(5): 993 - 1016. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. P. C. Krapels, I. A. L. M. van Rooij, M. C. Ocke, C. E. West, C. M.A.M. van der Horst, and R. P. M. Steegers-Theunissen Maternal Nutritional Status and the Risk for Orofacial Cleft Offspring in Humans J. Nutr., November 1, 2004; 134(11): 3106 - 3113. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. M. W. Groenen, I. A. L. M. van Rooij, P. G. M. Peer, M. C. Ocke, G. A. Zielhuis, and R. P. M. Steegers-Theunissen Low Maternal Dietary Intakes of Iron, Magnesium, and Niacin Are Associated with Spina Bifida in the Offspring J. Nutr., June 1, 2004; 134(6): 1516 - 1522. [Abstract] [Full Text] [PDF]
|
|