Am J Epidemiol 2003; 157:409-414.
Copyright © 2003 by Johns
Hopkins Bloomberg School of Public Health
ORIGINAL CONTRIBUTIONS |
Neurodegenerative Diseases and Exposure to Pesticides in the Elderly
1 Laboratoire Santé Travail Environnement, Institut de Santé Publique d’Epidémiologie et de Développement, Université Victor Segalen Bordeaux 2, Bordeaux, France.
2 Groupe Régional d’Etudes sur le Cancer, Centre François Baclesse, Université de Caen, Caen, France.
3 INSERM U330, Université Victor Segalen Bordeaux 2, Bordeaux, France.
The authors investigated the hypothesis that exposure to pesticides could be related to central nervous system disorders in a prospective cohort study of 1,507 French elderly (1992–1998). Lower cognitive performance was observed in subjects who had been occupationally exposed to pesticides. In men, the relative risks of developing Parkinson’s disease and Alzheimer’s disease for occupational exposure assessed by a job exposure matrix were 5.63 (95% confidence interval: 1.47, 21.58) and 2.39 (95% confidence interval: 1.02, 5.63), respectively, after confounding factors were taken into account. No association was found with having a primary job in agriculture or with environmental pesticide exposure, nor was an association found in women. These results suggest the presence of neurologic impairments in elderly persons who were exposed occupationally to pesticides.
aged; Alzheimer disease; nervous system diseases; occupational exposure; Parkinson disease; pesticides
Abbreviations: Abbreviations: CI, confidence interval; MMSE, Mini-Mental State Examination.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  J. R. Richardson, S. L. Shalat, B. Buckley, B. Winnik, P. O'Suilleabhain, R. Diaz-Arrastia, J. Reisch, and D. C. German Elevated Serum Pesticide Levels and Risk of Parkinson Disease Arch Neurol, July 1, 2009; 66(7): 870 - 875. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Sanchez, L. Gastaldi, M. Remedi, A. Caceres, and C. Landa Rotenone-Induced Toxicity is Mediated by Rho-GTPases in Hippocampal Neurons Toxicol. Sci., August 1, 2008; 104(2): 352 - 361. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Kroger, R. Andel, J. Lindsay, Z. Benounissa, R. Verreault, and D. Laurin Is Complexity of Work Associated with Risk of Dementia?: The Canadian Study of Health and Aging Am. J. Epidemiol., April 1, 2008; 167(7): 820 - 830. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Santibanez, F. Bolumar, and A. M Garcia Occupational risk factors in Alzheimer's disease: a review assessing the quality of published epidemiological studies Occup. Environ. Med., November 1, 2007; 64(11): 723 - 732. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Sanborn, K.J. Kerr, L.H. Sanin, D.C. Cole, K.L. Bassil, and C. Vakil Non-cancer health effects of pesticides: Systematic review and implications for family doctors Can Fam Physician, October 1, 2007; 53(10): 1712 - 1720. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F D Dick, G De Palma, A Ahmadi, N W Scott, G J Prescott, J Bennett, S Semple, S Dick, C Counsell, P Mozzoni, et al. Environmental risk factors for Parkinson's disease and parkinsonism: the Geoparkinson study Occup. Environ. Med., October 1, 2007; 64(10): 666 - 672. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. P Bressler, L. Olivi, J. H. Cheong, Y. Kim, A. Maerten, and D. Bannon Metal transporters in intestine and brain: their involvement in metal-associated neurotoxicities Human and Experimental Toxicology, March 1, 2007; 26(3): 221 - 229. [Abstract] [PDF]
|
|
|
|
|
|
F Kamel, C. Tanner, D. Umbach, J. Hoppin, M. Alavanja, A Blair, K Comyns, S. Goldman, M Korell, J. Langston, et al. Pesticide Exposure and Self-reported Parkinson's Disease in the Agricultural Health Study Am. J. Epidemiol., February 15, 2007; 165(4): 364 - 374. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. D. Dick Parkinson's disease and pesticide exposures Br. Med. Bull., January 22, 2007; (2007) ldl018v1. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. N.P. Kelada, H. Checkoway, S. L.R. Kardia, C. S. Carlson, P. Costa-Mallen, D. L. Eaton, J. Firestone, K. M. Powers, P. D. Swanson, G. M. Franklin, et al. 5' and 3' region variability in the dopamine transporter gene (SLC6A3), pesticide exposure and Parkinson's disease risk: a hypothesis-generating study Hum. Mol. Genet., October 15, 2006; 15(20): 3055 - 3062. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C M Fored, J P Fryzek, L Brandt, G Nise, B Sjogren, J K McLaughlin, W J Blot, and A Ekbom Parkinson's disease and other basal ganglia or movement disorders in a large nationwide cohort of Swedish welders Occup. Environ. Med., February 1, 2006; 63(2): 135 - 140. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Firestone, T. Smith-Weller, G. Franklin, P. Swanson, W. T. Longstreth Jr, and H. Checkoway Pesticides and Risk of Parkinson Disease: A Population-Based Case-Control Study Arch Neurol, January 1, 2005; 62(1): 91 - 95. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 OTHER ARTICLES NOTED (24 Jan 03 to 18 Apr 03) Evid. Based Nurs., July 1, 2003; 6(3): e1 - 12. [Full Text] [PDF]
|
|