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Am J Epidemiol 2002; 156:395-396.
Copyright © 2002 by the Johns Hopkins Bloomberg School of Public Health

COMMENTARY

In Nonrandomized Studies, Can We Use A Person’s Preimmunization Experience to Help Gauge the Safety and Efficacy of Immunization?

Noel S. Weiss and Robert L. Davis

From the Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, WA.

Received for publication April 17, 2002; accepted for publication June 12, 2002.

Abbreviations: Abbreviation: RRV-TV, tetravalent rhesus-human reassortant rotavirus.

The first 10% of the full text of this article appears below.


   INTRODUCTION
 
In a large case-control study, Murphy et al. (1, 2) observed a sharp increase in risk of intussusception soon after receipt of tetravalent rhesus-human reassortant rotavirus (RRV-TV) vaccine. For example, the risk during days 3–7 following the first dose of vaccine was 37.2 times that among unvaccinated infants (95 percent confidence interval: 12.6, 110.1). In contrast, the corresponding relative risk for the period beginning 21 days following the most recent dose was 0.3 (95 percent . . . [Full Text of this Article]


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