Am J Epidemiol 2002; 156:1105-1113.
Copyright © 2002 by Johns
Hopkins Bloomberg School of Public Health
ORIGINAL CONTRIBUTIONS |
Homocysteine and Blood Pressure in the Third National Health and Nutrition Examination Survey, 1988–1994
From the Division of Nutritional Sciences, Cornell University, Ithaca, NY.
Studies suggest that homocysteine may elevate blood pressure and increase the risk of hypertension. The association of homocysteine with blood pressure and with the risk of hypertension was investigated using cross-sectional data from the Third National Health and Nutrition Examination Survey (1998–1994). Homocysteine had an independent positive association with blood pressure after adjusting for cardiovascular risk factors. A 1 standard deviation (
5 µmol/liter) increase in homocysteine was associated with increases in diastolic and systolic blood pressure of 0.5 and 0.7 mmHg, respectively, in men and of 0.7 and 1.2 mmHg in women. Similarly, higher levels of homocysteine were associated with an increased risk of hypertension. In a comparison of the highest and lowest quintiles of homocysteine, women had a threefold increase in the risk of hypertension (95% confidence interval (CI): 1.7, 5.4), and men had a twofold increase (95% CI: 0.7, 5.1). In light of the homocysteine-blood pressure association, the association of homocysteine with prevalent cardiovascular disease was examined with and without adjusting for blood pressure. The results support a mediating role for blood pressure in women and suggest that the full effect of homocysteine on cardiovascular risk may be underestimated when blood pressure is adjusted.
biological markers; blood pressure; cardiovascular diseases; folic acid; homocysteine; hypertension; pyridoxine
Abbreviations: Abbreviations: CI, confidence interval; DASH, Dietary Approaches to Stop Hypertension; NHANES III, Third National Health and Nutrition Examination Survey.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  S. E. Chia, S. M. Ali, B. L. Lee, G. H. Lim, S. Jin, N.-V. Dong, N. T. H. Tu, C. N. Ong, and K. S. Chia Association of blood lead and homocysteine levels among lead exposed subjects in Vietnam and Singapore Occup. Environ. Med., October 1, 2007; 64(10): 688 - 693. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Levy, S.-J. Hwang, A. Kayalar, E. J. Benjamin, R. S. Vasan, H. Parise, M. G. Larson, T. J. Wang, J. Selhub, P. F. Jacques, et al. Associations of Plasma Natriuretic Peptide, Adrenomedullin, and Homocysteine Levels With Alterations in Arterial Stiffness: The Framingham Heart Study Circulation, June 19, 2007; 115(24): 3079 - 3085. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. A. McMahon, C. M. Skeaff, S. M. Williams, and T. J. Green Lowering Homocysteine with B Vitamins Has No Effect on Blood Pressure in Older Adults J. Nutr., May 1, 2007; 137(5): 1183 - 1187. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Chen, P. Factor-Litvak, G. R. Howe, J. H. Graziano, P. Brandt-Rauf, F. Parvez, A. van Geen, and H. Ahsan Arsenic Exposure from Drinking Water, Dietary Intakes of B Vitamins and Folate, and Risk of High Blood Pressure in Bangladesh: A Population-based, Cross-sectional Study Am. J. Epidemiol., March 1, 2007; 165(5): 541 - 552. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. J. Wang, P. Gona, M. G. Larson, D. Levy, E. J. Benjamin, G. H. Tofler, P. F. Jacques, J. B. Meigs, N. Rifai, J. Selhub, et al. Multiple Biomarkers and the Risk of Incident Hypertension Hypertension, March 1, 2007; 49(3): 432 - 438. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Kassab, T. Garadah, M. Abu-Hijleh, J. Golbahar, S. Senok, J. Wazir, and K. Gumaa The angiotensin type 1 receptor antagonist valsartan attenuates pathological ventricular hypertrophy induced by hyperhomocysteinemia in rats Journal of Renin-Angiotensin-Aldosterone System, December 1, 2006; 7(4): 206 - 211. [Abstract] [PDF]
|
|
|
|
 |
|
 A. B. Sobol, E. Bald, and J. Loba Fractions of Total Plasma Homocysteine in Patients with Ischemic Stroke Before the Age of 55 Years Angiology, March 1, 2005; 56(2): 201 - 209. [Abstract] [PDF]
|
|
|
|
 |
|
 M. Cesari, M. Zanchetta, A. Burlina, L. Pedon, G. Maiolino, D. Sticchi, A. C. Pessina, and G. P. Rossi Hyperhomocysteinemia Is Inversely Related With Left Ventricular Ejection Fraction and Predicts Cardiovascular Mortality in High-Risk Coronary Artery Disease Hypertensives Arterioscler. Thromb. Vasc. Biol., January 1, 2005; 25(1): 115 - 121. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Sundstrom, L. Sullivan, J. Selhub, E. J Benjamin, R. B D'Agostino, P. F Jacques, I. H Rosenberg, D. Levy, P. W.F Wilson, and R. S Vasan Relations of plasma homocysteine to left ventricular structure and function: the Framingham Heart Study Eur. Heart J., March 2, 2004; 25(6): 523 - 530. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Scholze, C. Rinder, J. Beige, R. Riezler, W. Zidek, and M. Tepel Acetylcysteine Reduces Plasma Homocysteine Concentration and Improves Pulse Pressure and Endothelial Function in Patients With End-Stage Renal Failure Circulation, January 27, 2004; 109(3): 369 - 374. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Sundstrom, L. Sullivan, R. B. D'Agostino, P. F. Jacques, J. Selhub, I. H. Rosenberg, P. W.F. Wilson, D. Levy, and R. S. Vasan Plasma Homocysteine, Hypertension Incidence, and Blood Pressure Tracking: The Framingham Heart Study Hypertension, December 1, 2003; 42(6): 1100 - 1105. [Abstract] [Full Text] [PDF]
|
|