American Journal of Epidemiology Vol. 154, No. 4 : 348-356
Copyright © 2001 by The Johns Hopkins University School of Hygiene and Public Health
ORIGINAL CONTRIBUTIONS |
Correlates of Markers of Oxidative Status in the General Population
From the Department of Social and Preventive Medicine, School of Medicine and Biomedical Sciences, State University of New York, Buffalo, NY.
Oxidative stress has been implicated in the etiology of many chronic diseases, including cardiovascular disease. However, limited information exists on the factors that may influence oxidative status in the general population. In a random sample of the population of two counties in western New York, levels of several markers of oxidative status (i.e., thiobarbituric acid-reactive substances, erythrocyte glutathione, and glutathione peroxidase) were determined. A total of 894 men and 903 women aged 35–79 years were included in the study (1996–1999). In addition, a number of sociodemographic and lifestyle characteristics and cardiovascular disease risk factors were measured. Age, markers of glucose metabolism (e.g., plasma glucose level) and insulin resistance (e.g., serum triglycerides, high density lipoprotein cholesterol, body mass index), and postmenopausal status in women were associated with increased oxidative stress and reduced antioxidant potentials. Oxidative status and antioxidant potentials appear to be significantly associated with a number of major cardiovascular disease risk factors; most of them are linked to abnormalities in glucose and insulin metabolism.
atherosclerosis; body mass index; cardiovascular diseases; glucose; oxidative stress
Abbreviations: EDTA, ethylenediaminetetraacetic acid; HDL, high density lipoprotein; LDL, low density lipoprotein; TBARS, thiobarbituric acid-reactive substances
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